{"id":"W4388476260","doi":"10.1186/s40560-023-00699-8","title":"Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials","year":2023,"lang":"en","type":"review","venue":"Journal of Intensive Care","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital","funders":"","keywords":"Medicine; Randomized controlled trial; Relative risk; Regimen; Confidence interval; Meta-analysis; Intensive care unit; Internal medicine; Subgroup analysis; Intensive care medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","metaepi_broad"],"consensus_categories":["metaepi_broad"],"category_scores_codex":[0.008497226,0.0006339071,0.07343461,0.001980141,0.0000195674,0.00002327589,0.0002932498,0.0002126075,0.00003518157],"category_scores_gemma":[0.1601102,0.0003101152,0.01827923,0.001209148,0.0002227576,0.00003246787,0.00005326909,0.0006305297,0.000001715187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001227093,"about_ca_system_score_gemma":0.0003972949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008604988,"about_ca_topic_score_gemma":5.63205e-7,"domain_scores_codex":[0.9846429,0.00412195,0.009741525,0.0003140865,0.000925676,0.0002538468],"domain_scores_gemma":[0.9316915,0.01661273,0.01016578,0.000528454,0.04080316,0.0001983498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.006526566,0.0001606293,0.000006862243,0.6152039,0.3774769,0.00007045315,0.000180265,0.000009048998,0.000001804463,0.000008667909,0.00009963362,0.0002553028],"study_design_scores_gemma":[0.06344173,0.0001943835,0.00000787211,0.2252135,0.7104265,0.00001071472,0.0004795716,0.00002302206,0.000008414765,0.00000147721,0.00004111151,0.0001517441],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009416863,0.9900157,0.00002970585,0.0006227147,0.000195807,0.00892406,0.00009796665,0.000006157825,0.00001364686],"genre_scores_gemma":[0.007411775,0.9908485,0.0001040486,0.001395197,0.00005400964,0.00002854811,0.00003686879,0.00006658582,0.00005447199],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3899904,"threshold_uncertainty_score":0.9999351,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1111108306465936,"score_gpt":0.4250284462309861,"score_spread":0.3139176155843925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}