{"id":"W4388478027","doi":"10.20944/preprints202311.0277.v1","title":"Is the Central Nervous System Reservoir a Hurdle for an HIV Cure?","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre Hospitalier de l’Université de Montréal; Montreal Clinical Research Institute; Université de Montréal; University of Alberta","funders":"","keywords":"Context (archaeology); Life expectancy; Central nervous system; Antiretroviral therapy; Disease; Viral replication; Human immunodeficiency virus (HIV); Medicine; Immunology; Neurotoxicity; Viral load; Virus; Biology; Virology; Neuroscience; Population; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001153625,0.0003666747,0.001116618,0.0005196753,0.0005205647,0.002919688,0.0005102186,0.001712741,0.005351232],"category_scores_gemma":[0.002277076,0.000186659,0.0003821629,0.0004766485,0.001533607,0.002802644,0.0008947026,0.002748499,0.004024311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008333336,"about_ca_system_score_gemma":0.002047008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000823952,"about_ca_topic_score_gemma":0.0007107909,"domain_scores_codex":[0.9994287,0.0001818399,0.00003437771,0.00007928433,0.0002077005,0.00006810209],"domain_scores_gemma":[0.9988174,0.0005903974,0.0001173374,0.00009283986,0.0002453883,0.0001366872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004894095,0.00008875235,0.002357976,0.009892981,0.0001699463,0.00121007,0.000657815,0.0004132299,0.02538936,0.04486409,0.156105,0.7583614],"study_design_scores_gemma":[0.00001978918,0.0001844742,0.002854862,0.002375934,0.00009764561,0.003038431,0.0006279729,0.0002258861,0.009103804,0.03470014,0.9467236,0.00004759108],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.008355916,0.8924761,0.007447783,0.06970568,0.008467992,0.00003356371,0.0007142419,0.0004101875,0.01238849],"genre_scores_gemma":[0.05789662,0.8882645,0.00856006,0.01589358,0.01305342,0.00008706037,0.0009158829,0.0003137136,0.01501506],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005351232,"threshold_uncertainty_score":0.01790172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1961213939496189,"score_gpt":0.3780835736642179,"score_spread":0.181962179714599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}