{"id":"W4388478082","doi":"10.20944/preprints202311.0259.v1","title":"Phosphodiesterase 4 Inhibition in the Management of Psoriasis","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; SKiN Health; Queen's University; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"","keywords":"Apremilast; Psoriasis; Medicine; Roflumilast; Adverse effect; Clinical trial; Phosphodiesterase; Dermatology; Atopic dermatitis; Intensive care medicine; Pharmacology; Internal medicine; Psoriatic arthritis; Pulmonary disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006531646,0.0002349017,0.0004000627,0.0001813709,0.00003851808,0.000007649788,0.0002031525,0.0001765369,0.0003182823],"category_scores_gemma":[0.00005489258,0.0001741758,0.0002479565,0.0002323166,0.00009674137,0.00003088261,0.0008968848,0.0004819955,0.0005735584],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008075863,"about_ca_system_score_gemma":0.00008431901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009822692,"about_ca_topic_score_gemma":0.00001076823,"domain_scores_codex":[0.9981081,0.0001262109,0.0005297697,0.0005512879,0.0004636003,0.0002210338],"domain_scores_gemma":[0.9984494,0.00005270635,0.0002160296,0.001131788,0.00007399123,0.00007605492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000533063,0.001137881,0.9797367,0.005657454,0.0004412408,0.001676802,0.002809108,0.0004873977,0.0009325727,0.0004753824,0.0007566112,0.005355828],"study_design_scores_gemma":[0.000920293,0.00003123054,0.9821939,0.001915871,0.0002708208,0.000007671071,0.001354897,0.00001905651,0.008874688,0.000948368,0.003290188,0.0001729391],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903577,0.0002450746,0.00002541964,0.0008155699,0.0003703515,0.001172908,0.0000304354,0.00009061845,0.006891944],"genre_scores_gemma":[0.9974136,0.0004666915,0.00007003046,0.0003166599,0.0001215496,0.0003758045,0.00007982948,0.00003331418,0.001122535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007942116,"threshold_uncertainty_score":0.7372125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1287262563069071,"score_gpt":0.3675650360844255,"score_spread":0.2388387797775184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}