{"id":"W4388486354","doi":"10.1093/neuonc/noad210","title":"Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalization via macropinocytosis","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Medical Research Council; Deutschen Konsortium für Translationale Krebsforschung; National Centre for the Replacement Refinement and Reduction of Animals in Research; Brain Tumour Charity; University of Glasgow; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Cancer Research UK; University of Sheffield; Deutsches Krebsforschungszentrum","keywords":"Internalization; Intravital microscopy; Cytoskeleton; In vivo; Cancer research; Integrin; Motility; Biology; Pathology; Cell biology; Cell; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262074,0.0002557252,0.0002328187,0.0001824287,0.00009588848,0.0003100788,0.000177551,0.0001835998,0.00092355],"category_scores_gemma":[0.00007667387,0.00008417646,0.000190971,0.0000971556,0.0001887433,0.0001400134,0.0001149631,0.0005587328,0.0002766112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002532911,"about_ca_system_score_gemma":0.000221657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003673921,"about_ca_topic_score_gemma":0.0009213857,"domain_scores_codex":[0.9999151,0.00001085687,0.000008622974,0.00001621183,0.00002878623,0.00002045473],"domain_scores_gemma":[0.9999226,0.00001293336,0.00003283446,0.000007146079,0.000008971769,0.00001560383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007752829,0.00003721434,0.0001828818,0.00004987914,0.000007121078,0.000020681,0.00000544831,0.000081522,0.9980012,0.00005754198,0.00006384344,0.001415097],"study_design_scores_gemma":[0.00002309744,0.0004408691,0.005222567,0.000007436216,0.0000257738,0.0002038987,0.0000201746,0.001351056,0.9904447,0.00003341901,0.002223929,0.000003085697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917864,0.002665595,0.003207362,0.0001963761,0.0000274682,0.00003244499,0.0003263119,0.0001905685,0.001567495],"genre_scores_gemma":[0.9952539,0.001475378,0.001818122,0.00004406928,0.000007068597,0.00002792809,0.000351042,0.00001716329,0.001005306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00092355,"threshold_uncertainty_score":0.003089547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02579795818833784,"score_gpt":0.3085467064945886,"score_spread":0.2827487483062507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}