{"id":"W4388488683","doi":"10.1038/s41586-023-06717-x","title":"Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Genome Canada; Women and Children’s Health Research Institute; University of Alberta; University of British Columbia; Hospital for Sick Children; BC Children's Hospital; University of Toronto; SickKids Foundation; University of Manitoba","funders":"National Institute of General Medical Sciences; National Center for Advancing Translational Sciences; Medical Research Council; Honjo International Scholarship Foundation; Science for Life Laboratory; Georgia Clinical and Translational Science Alliance; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; European Commission; Assistance Publique - Hôpitaux de Paris; Bundesministerium für Bildung und Forschung; National Health and Medical Research Council; Else Kröner-Fresenius-Stiftung; Institut des maladies génétiques Imagine; Göran Gustafssons Stiftelser; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Fondation pour la Recherche Médicale; NHLBI Division of Intramural Research; Deutsches Zentrum für Infektionsforschung; Institut National de la Santé et de la Recherche Médicale; National Institute on Aging; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Fondation du Souffle; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; Jeffrey Modell Foundation","keywords":"Autoantibody; Immunology; Biology; NF-κB; Type (biology); Medicine; Cancer research; Antibody; Inflammation; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001158305,0.0001228719,0.0001377545,0.0002166499,0.0001250187,0.00001301845,0.0001228365,0.0005851517,0.00035746],"category_scores_gemma":[0.00007084589,0.00009242534,0.0000360413,0.0004039714,0.00006487556,0.0001059501,0.00003746323,0.001584027,0.001561146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004616511,"about_ca_system_score_gemma":0.00004198125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003965962,"about_ca_topic_score_gemma":0.00009265035,"domain_scores_codex":[0.9993009,0.0000670876,0.0001336539,0.0002211076,0.00003803395,0.0002392211],"domain_scores_gemma":[0.9996384,0.00005311547,0.00005901727,0.0001520701,0.00008982002,0.000007537858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000843101,0.0003175114,0.01620767,0.00005075101,0.000186813,0.0001104119,0.006320877,0.0003858025,0.829172,0.008679916,0.1308304,0.006894831],"study_design_scores_gemma":[0.002312078,0.0006930129,0.06823375,0.0001963145,0.00002216613,0.00003703643,0.003402735,0.00008204833,0.1968629,0.0002352013,0.7273991,0.0005236901],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9575404,0.001956051,0.00001344925,0.0004218636,0.005127551,0.0001551126,0.000007623009,0.0001993778,0.03457859],"genre_scores_gemma":[0.9692334,0.0001912622,0.000009319069,0.0005440568,0.00002899838,0.000007144053,0.0002479983,0.00001309853,0.02972474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6323091,"threshold_uncertainty_score":0.9992163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087520954682734,"score_gpt":0.2544080518891599,"score_spread":0.2435328423423326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}