{"id":"W4388488683","doi":"10.1038/s41586-023-06717-x","title":"Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency","year":2023,"lang":"en","type":"article","venue":"Nature","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Genome Canada; Women and Children’s Health Research Institute; University of Alberta; University of British Columbia; Hospital for Sick Children; BC Children's Hospital; University of Toronto; SickKids Foundation; University of Manitoba","funders":"National Institute of General Medical Sciences; National Center for Advancing Translational Sciences; Medical Research Council; Honjo International Scholarship Foundation; Science for Life Laboratory; Georgia Clinical and Translational Science Alliance; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; European Commission; Assistance Publique - Hôpitaux de Paris; Bundesministerium für Bildung und Forschung; National Health and Medical Research Council; Else Kröner-Fresenius-Stiftung; Institut des maladies génétiques Imagine; Göran Gustafssons Stiftelser; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Fondation pour la Recherche Médicale; NHLBI Division of Intramural Research; Deutsches Zentrum für Infektionsforschung; Institut National de la Santé et de la Recherche Médicale; National Institute on Aging; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Fondation du Souffle; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; Jeffrey Modell Foundation","keywords":"Autoantibody; Immunology; Biology; NF-κB; Type (biology); Medicine; Cancer research; Antibody; Inflammation; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003220169,0.0006322119,0.0002436848,0.0007488589,0.0004318412,0.00040539,0.0001639961,0.0006986188,0.002264349],"category_scores_gemma":[0.0007709379,0.0001519848,0.0002115107,0.0002839372,0.0003507426,0.0002883072,0.0003042818,0.0004193456,0.0004372592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001914162,"about_ca_system_score_gemma":0.00008788558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004173522,"about_ca_topic_score_gemma":0.000207367,"domain_scores_codex":[0.9997806,0.00006264323,0.00002967155,0.00006597465,0.00003327052,0.0000279125],"domain_scores_gemma":[0.9996687,0.00007431542,0.0001297174,0.00003910407,0.0000292752,0.00005883915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005523281,0.0005654232,0.6134735,0.0005168258,0.0003527159,0.1331732,0.001130941,0.000311533,0.1625111,0.001939348,0.007245503,0.07325663],"study_design_scores_gemma":[0.0003291352,0.00240731,0.5122549,0.0002934553,0.0002958279,0.4369018,0.0006692671,0.001206127,0.01631368,0.003164364,0.02610175,0.00006246111],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886397,0.004237466,0.001618176,0.0004278234,0.0001477916,0.00003402184,0.0003135673,0.0001484247,0.004433008],"genre_scores_gemma":[0.9981115,0.0006269609,0.0004555145,0.000218062,0.00006266413,0.00001017954,0.000166474,0.000006935848,0.0003417138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002264349,"threshold_uncertainty_score":0.007575035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087520954682734,"score_gpt":0.2544080518891599,"score_spread":0.2435328423423326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}