{"id":"W4388488828","doi":"10.1049/syb2.12077","title":"Kinetic modelling of <i>β</i> ‐cell metabolism reveals control points in the insulin‐regulating pyruvate cycling pathways","year":2023,"lang":"en","type":"article","venue":"IET Systems Biology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Natural Resources Limited","keywords":"Pyruvate carboxylase; Pyruvate dehydrogenase complex; Citric acid cycle; Flux (metallurgy); Isocitrate dehydrogenase; Pyruvate decarboxylation; Biochemistry; Pyruvate dehydrogenase phosphatase; Chemistry; Carbohydrate metabolism; Biology; Metabolism; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004112794,0.0007698851,0.0007969167,0.0003433795,0.0003793555,0.001305612,0.0006819434,0.001035074,0.001471343],"category_scores_gemma":[0.0007902423,0.0003618487,0.001061784,0.0003105273,0.0005770433,0.00053551,0.0005236139,0.0006524918,0.0003171294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001129186,"about_ca_system_score_gemma":0.0007409846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01128728,"about_ca_topic_score_gemma":0.002547649,"domain_scores_codex":[0.9998678,0.00003999304,0.000007391805,0.00003404387,0.0000238093,0.00002690286],"domain_scores_gemma":[0.9997415,0.0001300086,0.00004356007,0.00001871299,0.00004923797,0.000016923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0000372254,0.00001965052,0.0004078559,0.00003069963,0.00002001955,0.00003973089,0.00001536963,0.9898037,0.004519372,0.00375484,0.0001332742,0.001218252],"study_design_scores_gemma":[0.00000497729,0.00001138286,0.0001424991,0.000002362708,0.000005005098,0.000006304191,0.000003130545,0.998317,0.0004472985,0.0008435908,0.0002120327,0.000004459576],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3884581,0.001407163,0.5739603,0.001130214,0.0001918443,0.0001427211,0.0007796458,0.0006360878,0.03329397],"genre_scores_gemma":[0.9889883,0.0003407127,0.006535211,0.000057403,0.00001094317,0.00008954622,0.0001528742,0.00003443949,0.003790668],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01128728,"threshold_uncertainty_score":0.02244312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04275673039513991,"score_gpt":0.255138562254108,"score_spread":0.2123818318589681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}