{"id":"W4388489852","doi":"10.1016/j.cell.2023.09.025","title":"Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Tianjin University; Tsinghua University; Macquarie University; Volkswagen Foundation; York University; Johns Hopkins University; Imperial College London; National Cancer Institute; National Institutes of Health; National University of Singapore; National Science Foundation","keywords":"Biology; Genetics; CRISPR; Genome; Computational biology; Chromosome; Cas9; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007135641,0.0001000788,0.0000920779,0.00004430869,0.00008600094,0.00002586108,0.00006963409,0.00005087742,0.00001523143],"category_scores_gemma":[0.0000909704,0.0001074566,0.00003563135,0.00007857268,0.00003223271,0.000001951686,0.00009936949,0.00006133984,0.00002894787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005601496,"about_ca_system_score_gemma":0.00001823199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006419305,"about_ca_topic_score_gemma":0.000005699681,"domain_scores_codex":[0.9993832,0.00002093915,0.0001299979,0.0002201978,0.00005303514,0.0001926023],"domain_scores_gemma":[0.9996587,0.00004799182,0.00002955381,0.000176861,0.00002248494,0.0000644243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005113342,0.00001287781,0.002475517,0.0000408644,0.00001389818,0.000004865533,0.00008370322,0.0004874725,0.9946457,0.000009442612,0.001158108,0.001062471],"study_design_scores_gemma":[0.0008079966,0.000097299,0.008717496,0.00004524132,0.0000343937,0.00004031404,0.0002466219,0.005445414,0.9657032,0.0001992247,0.0183477,0.000315091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996621,0.0006270673,0.001165889,0.00004724032,0.0005273515,0.0001076653,0.000008457345,0.00005197439,0.0008433774],"genre_scores_gemma":[0.9983067,0.0001644704,0.0006973278,0.00002718333,0.0002145076,0.00001818915,0.00003392318,0.00002199067,0.0005157049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02894245,"threshold_uncertainty_score":0.4381953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008436221517023185,"score_gpt":0.2758489271471978,"score_spread":0.2674127056301747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}