{"id":"W4388489852","doi":"10.1016/j.cell.2023.09.025","title":"Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions","year":2023,"lang":"en","type":"article","venue":"Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Tianjin University; Tsinghua University; Macquarie University; Volkswagen Foundation; York University; Johns Hopkins University; Imperial College London; National Cancer Institute; National Institutes of Health; National University of Singapore; National Science Foundation","keywords":"Biology; Genetics; CRISPR; Genome; Computational biology; Chromosome; Cas9; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003694031,0.0007263356,0.0004188628,0.0004456711,0.0002906096,0.0008541294,0.0009771865,0.0006276635,0.002053275],"category_scores_gemma":[0.000986386,0.0004017364,0.0002770102,0.0003536523,0.0005489251,0.0007026648,0.001201112,0.001218302,0.0005240823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004844686,"about_ca_system_score_gemma":0.0003353287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004154553,"about_ca_topic_score_gemma":0.001251264,"domain_scores_codex":[0.999576,0.00005473767,0.00002876561,0.0001072397,0.0001743514,0.00005898127],"domain_scores_gemma":[0.9993089,0.0003293575,0.0001078133,0.0001303764,0.00004239575,0.00008116098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008925091,0.00005182222,0.0007440726,0.00003754288,0.00001351755,0.0002361766,0.0000404766,0.007147846,0.9719579,0.004366647,0.0001510779,0.0151637],"study_design_scores_gemma":[0.00002068428,0.00009010857,0.000802926,0.000005138197,0.00001822379,0.0002682334,0.00003390014,0.0342672,0.9606877,0.0009726522,0.002816555,0.00001659157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8090587,0.0004103557,0.183348,0.0003366366,0.00009881098,0.00007282641,0.0001600394,0.002249065,0.004265537],"genre_scores_gemma":[0.9286045,0.0002994563,0.06527788,0.00009276926,0.00001341535,0.00005158711,0.0002123933,0.0004394769,0.005008506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002053275,"threshold_uncertainty_score":0.006868839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008436221517023185,"score_gpt":0.2758489271471978,"score_spread":0.2674127056301747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}