{"id":"W4388498486","doi":"10.2217/epi-2023-0310","title":"MeCP2 is the Protector of Epigenome Integrity, Membrane-Less Nuclear Architecture, and Stability of Chromatin Assembly","year":2023,"lang":"en","type":"editorial","venue":"Epigenomics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; University of Manitoba","keywords":"Epigenome; Biology; Chromatin; Epigenetics; Epigenomics; Cell biology; Computational biology; Genetics; DNA methylation; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005531682,0.0003559517,0.0005034297,0.00006753211,0.00009858135,0.00002626004,0.0006357539,0.0006001407,0.00001631709],"category_scores_gemma":[0.0004847458,0.000291438,0.0001892438,0.0001259116,0.0003177176,0.000001810422,0.0006244569,0.0005108344,0.000004475375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002610989,"about_ca_system_score_gemma":0.0003605486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002457146,"about_ca_topic_score_gemma":0.0002776019,"domain_scores_codex":[0.9980134,0.0001457546,0.000586851,0.0005976298,0.0003503823,0.0003060311],"domain_scores_gemma":[0.9984627,0.0001683503,0.0004176707,0.0006949668,0.0001786451,0.00007766894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002174143,0.0001105033,0.00007424655,0.0009955593,0.0002978463,0.000001428067,0.001039575,0.00002456009,0.9319751,0.00001344302,0.06371937,0.001530963],"study_design_scores_gemma":[0.0008598466,0.0007708849,0.002834953,0.0001239687,0.0001268532,0.000001664283,0.0005917409,0.00003556773,0.5335546,0.000405891,0.4599038,0.0007901965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9151175,0.0007139318,0.00007000845,0.0001458652,0.0816716,0.0008434067,0.001234487,0.00001398612,0.0001891855],"genre_scores_gemma":[0.9395844,0.009531732,0.002317494,0.0001289274,0.04644951,0.0001210728,0.001104272,0.000437086,0.0003254859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3984205,"threshold_uncertainty_score":0.9999537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513334932071241,"score_gpt":0.2405643338580805,"score_spread":0.2254309845373681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}