{"id":"W4388498486","doi":"10.2217/epi-2023-0310","title":"MeCP2 is the Protector of Epigenome Integrity, Membrane-Less Nuclear Architecture, and Stability of Chromatin Assembly","year":2023,"lang":"en","type":"editorial","venue":"Epigenomics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; University of Manitoba","keywords":"Epigenome; Biology; Chromatin; Epigenetics; Epigenomics; Cell biology; Computational biology; Genetics; DNA methylation; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002659949,0.00176232,0.001608725,0.001662122,0.001414794,0.003264514,0.001612582,0.004946805,0.009479107],"category_scores_gemma":[0.006730534,0.000662316,0.001151643,0.0006126338,0.001144098,0.002107131,0.0009869213,0.008090266,0.00514156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001545941,"about_ca_system_score_gemma":0.00139399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007045016,"about_ca_topic_score_gemma":0.001804379,"domain_scores_codex":[0.9987152,0.0001703251,0.0001680325,0.0001891212,0.0006504947,0.0001068787],"domain_scores_gemma":[0.9950926,0.00188574,0.0003240647,0.0001086394,0.001716959,0.0008719734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001547364,0.00001510129,0.00004665729,0.000475128,0.0000281705,0.0001994786,0.00001214373,0.00003851656,0.0007478481,0.0006818758,0.9839753,0.01362496],"study_design_scores_gemma":[0.00007529472,0.00005435822,0.0003727272,0.0002838321,0.00005911354,0.0004183022,0.0000231016,0.0001715658,0.0006733271,0.001087525,0.9967619,0.00001885868],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.000142957,0.01544387,0.0003090002,0.01973514,0.9619418,0.00002733286,0.00008554299,0.00006249519,0.002251776],"genre_scores_gemma":[0.001129117,0.0154436,0.0002319599,0.0170395,0.9486482,0.00003692431,0.00008856575,0.00005387427,0.01732823],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.009479107,"threshold_uncertainty_score":0.03171074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513334932071241,"score_gpt":0.2405643338580805,"score_spread":0.2254309845373681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}