{"id":"W4388499266","doi":"10.1161/circulationaha.123.066822","title":"Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease","year":2023,"lang":"en","type":"review","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Kowa Company; Heart and Stroke Foundation of Canada","keywords":"Medicine; Calcification; Aortic valve stenosis; Lipoprotein; LDL receptor; Stenosis; valvular heart disease; Internal medicine; Receptor; Major facilitator superfamily; Cardiology; Endocrinology; Pharmacology; Transporter; Biochemistry; Biology; Cholesterol; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005001368,0.0005448431,0.001185348,0.0006762919,0.000101501,0.0004823943,0.0005840763,0.0006093819,0.002296313],"category_scores_gemma":[0.0004706019,0.0001416917,0.0008594512,0.0003950948,0.0001527723,0.0002832405,0.0002600114,0.0008004123,0.000684471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002452525,"about_ca_system_score_gemma":0.0004157662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004590151,"about_ca_topic_score_gemma":0.000982657,"domain_scores_codex":[0.9998823,0.00003335899,0.00001541577,0.0000166444,0.00003519808,0.00001714785],"domain_scores_gemma":[0.9998603,0.00006341675,0.00002792079,0.000003927451,0.0000312478,0.00001322231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001670641,0.0003109861,0.0007647084,0.04137742,0.001817289,0.0002032641,0.00005221455,0.0006067461,0.01238007,0.001594121,0.01667907,0.9225435],"study_design_scores_gemma":[0.001933414,0.004247518,0.01346599,0.01353102,0.007364741,0.002779484,0.0001410046,0.001267472,0.015457,0.002241184,0.9374644,0.0001068468],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002474168,0.9963526,0.0001584706,0.0001706551,0.0001121331,0.00001771267,0.00005446808,0.00001552108,0.000644336],"genre_scores_gemma":[0.01588815,0.9818586,0.0004536592,0.0003858759,0.00009326284,0.00003921298,0.0001729478,0.000004747267,0.001103581],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002296313,"threshold_uncertainty_score":0.007681906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06654615407056962,"score_gpt":0.3329621386943851,"score_spread":0.2664159846238155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}