{"id":"W4388501064","doi":"10.1097/cce.0000000000000997","title":"Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis","year":2023,"lang":"en","type":"article","venue":"Critical Care Explorations","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian VIGOUR Centre; University of Alberta; St. Michael's Hospital; McGill University Health Centre; University Health Network; University of Toronto; University of British Columbia","funders":"Duke Clinical Research Institute; Norwegian Institute of Public Health; Faculty of Medicine and Health, University of Sydney; European Regional Development Fund; American Regent; Esperion Therapeutics; Silence Therapeutics; HLS Therapeutics; Idorsia Pharmaceuticals; Servier; Novo Nordisk; MyoKardia; Daiichi-Sankyo; Medicines Company; Tartu Ülikool; AstraZeneca; Amarin Corporation; LifeArc; National Institutes of Health; Regeneron Pharmaceuticals; Sanofi; Norges Teknisk-Naturvitenskapelige Universitet; Pfizer; York University; Cleveland Clinic; Bristol-Myers Squibb; Kaiser Permanente; Eli Lilly and Company; CSL Behring; University of Toronto; Eesti Teadusagentuur; Brigham and Women's Hospital; Heart and Stroke Foundation of Canada; European Commission; Kowa Company; Instituto de Salud Carlos III; Helse Midt-Norge; Amgen","keywords":"Kexin; Proprotein convertase; Subtilisin; Downregulation and upregulation; Sepsis; PCSK9; Medicine; Biology; Internal medicine; Gene; Genetics; Enzyme; Biochemistry; Cholesterol; LDL receptor; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003825291,0.00009374468,0.0001895488,0.00006937396,0.00007932454,0.00002046779,0.00001958903,0.0000594548,0.000167292],"category_scores_gemma":[0.0003699481,0.00007862877,0.00002647582,0.0002133188,0.0001485923,0.00007085854,0.00002977009,0.00005480874,0.000026207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002378868,"about_ca_system_score_gemma":0.00005020453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007038244,"about_ca_topic_score_gemma":0.00003663838,"domain_scores_codex":[0.9992958,0.00005395172,0.0001712703,0.0002143736,0.0001463933,0.0001182283],"domain_scores_gemma":[0.9991493,0.0002988263,0.00001829578,0.0001254029,0.0002882467,0.0001199224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007419096,0.001659278,0.6752212,0.001496122,0.0005960292,0.0007052176,0.01391989,0.00009363917,0.2361394,0.01176938,0.007037291,0.0506206],"study_design_scores_gemma":[0.001813524,0.0008661696,0.9477957,0.00009710413,0.0006272416,0.000006072543,0.004872576,0.001277544,0.04030854,0.00184513,0.0003190648,0.0001712924],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945784,0.00140171,0.00005725131,0.003222013,0.0001046311,0.0003812202,0.0001030941,0.00005799438,0.00009367196],"genre_scores_gemma":[0.9983509,0.0002223994,0.0007662614,0.0001224189,0.00006705112,0.0001057688,0.0003371404,0.00001122132,0.00001680066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2725745,"threshold_uncertainty_score":0.3206388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1676682569882291,"score_gpt":0.4054424491649032,"score_spread":0.2377741921766741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}