{"id":"W4388501064","doi":"10.1097/cce.0000000000000997","title":"Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis","year":2023,"lang":"en","type":"article","venue":"Critical Care Explorations","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian VIGOUR Centre; University of Alberta; St. Michael's Hospital; McGill University Health Centre; University Health Network; University of Toronto; University of British Columbia","funders":"Duke Clinical Research Institute; Norwegian Institute of Public Health; Faculty of Medicine and Health, University of Sydney; European Regional Development Fund; American Regent; Esperion Therapeutics; Silence Therapeutics; HLS Therapeutics; Idorsia Pharmaceuticals; Servier; Novo Nordisk; MyoKardia; Daiichi-Sankyo; Medicines Company; Tartu Ülikool; AstraZeneca; Amarin Corporation; LifeArc; National Institutes of Health; Regeneron Pharmaceuticals; Sanofi; Norges Teknisk-Naturvitenskapelige Universitet; Pfizer; York University; Cleveland Clinic; Bristol-Myers Squibb; Kaiser Permanente; Eli Lilly and Company; CSL Behring; University of Toronto; Eesti Teadusagentuur; Brigham and Women's Hospital; Heart and Stroke Foundation of Canada; European Commission; Kowa Company; Instituto de Salud Carlos III; Helse Midt-Norge; Amgen","keywords":"Kexin; Proprotein convertase; Subtilisin; Downregulation and upregulation; Sepsis; PCSK9; Medicine; Biology; Internal medicine; Gene; Genetics; Enzyme; Biochemistry; Cholesterol; LDL receptor; Lipoprotein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005405103,0.0002414318,0.0003091894,0.000117225,0.0001241715,0.0002479264,0.0002127843,0.0003148906,0.001744016],"category_scores_gemma":[0.0005468128,0.0001253016,0.0003083657,0.0001103108,0.0003028261,0.0001564657,0.0001854141,0.0005669079,0.0001627359],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002485633,"about_ca_system_score_gemma":0.0004527572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000289229,"about_ca_topic_score_gemma":0.0006405434,"domain_scores_codex":[0.999808,0.00007065872,0.00001789602,0.00004032053,0.00003343177,0.00002974254],"domain_scores_gemma":[0.9996209,0.00006365724,0.0001848089,0.00002868247,0.00001970605,0.00008225165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.2693189,0.01455468,0.1577417,0.001524667,0.002325969,0.0003346663,0.00008569708,0.001884783,0.4290954,0.0007225119,0.002630982,0.1197799],"study_design_scores_gemma":[0.03370568,0.1743343,0.6886492,0.0002533167,0.002184813,0.001445377,0.0001739308,0.002646417,0.0903169,0.0009979297,0.005243712,0.00004837038],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973027,0.001595254,0.0002904898,0.0001997629,0.0000356115,0.00004913201,0.000206428,0.00001091298,0.0003096588],"genre_scores_gemma":[0.9973243,0.001082158,0.0005157426,0.0001708486,0.00004618902,0.0001058442,0.0002638281,0.000003223103,0.0004877063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001744016,"threshold_uncertainty_score":0.005834281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1676682569882291,"score_gpt":0.4054424491649032,"score_spread":0.2377741921766741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}