{"id":"W4388510152","doi":"10.1158/1535-7163.mct-23-0102","title":"Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Work & Health; University of Toronto","funders":"Merck KGaA","keywords":"Biology; Cancer research; Angiogenesis; Cell growth; Cancer; Clear cell renal cell carcinoma; Renal cell carcinoma; Internal medicine; Biochemistry; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002962787,0.0004901381,0.0007806282,0.000733992,0.0001224144,0.00004148336,0.0002057987,0.000164416,0.0001271948],"category_scores_gemma":[0.00002344577,0.0004091253,0.0003508532,0.002320731,0.0001892041,0.0001372127,0.0001269332,0.0003949473,0.00006221604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002175502,"about_ca_system_score_gemma":0.0003893671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002839996,"about_ca_topic_score_gemma":0.00004132354,"domain_scores_codex":[0.9968902,0.00009052393,0.0007101327,0.0006981842,0.0009893939,0.0006214997],"domain_scores_gemma":[0.9980056,0.00005429563,0.0002831184,0.0005957755,0.0006395488,0.0004217018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005328908,0.0003414547,0.0004966593,0.0002676836,0.0002833572,0.0001647971,0.0007677625,0.002358529,0.9927174,0.0002225895,0.00120103,0.0006458398],"study_design_scores_gemma":[0.003118889,0.0007897958,0.0003136162,0.0009245128,0.0005006443,0.00002394558,0.000357057,0.002812971,0.9893145,0.00006177145,0.001275666,0.0005066067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874011,0.0004500078,0.007249015,0.003090514,0.00008443027,0.0006180343,0.000202138,0.0002003177,0.0007044479],"genre_scores_gemma":[0.9907651,0.00006304633,0.003323438,0.003995267,0.0002392198,0.0001723537,0.0001462547,0.0001412599,0.001154051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003925577,"threshold_uncertainty_score":0.9998361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552164146266343,"score_gpt":0.2683366211512536,"score_spread":0.2428149796885901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}