{"id":"W4388515898","doi":"10.1093/ecco-jcc/jjad190","title":"Impact of Baseline Corticosteroid Use on the Efficacy and Safety of Upadacitinib in Patients with Ulcerative Colitis: A Post Hoc Analysis of the Phase 3 Clinical Trial Programme","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"Pfizer Canada; Sandoz Canada; Mylan; Kissei; AbbVie; Celgene; EA Pharma Co., Ltd.; Gilead Sciences; Amgen Canada; Daiichi-Sankyo; Pfizer; AbbVie Canada; Amgen","keywords":"Medicine; Ulcerative colitis; Post-hoc analysis; Post hoc; Corticosteroid; Clinical trial; Internal medicine; Safety profile; Adverse effect; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01872742,0.001489092,0.004001359,0.0004357967,0.000435761,0.001457658,0.001044138,0.000961916,0.005568766],"category_scores_gemma":[0.01724016,0.0004426563,0.008242203,0.0006029024,0.0008095781,0.00122212,0.0008121777,0.002612351,0.0005456725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000828822,"about_ca_system_score_gemma":0.001671364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004893003,"about_ca_topic_score_gemma":0.001064651,"domain_scores_codex":[0.9854447,0.01084864,0.0008279165,0.001052091,0.0009366036,0.0008899375],"domain_scores_gemma":[0.9780703,0.01371246,0.004015117,0.002157315,0.001148855,0.0008960651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.957609,0.001370746,0.01020735,0.000784448,0.01442476,0.00009366255,0.00009036108,0.0009871015,0.001576409,0.00006877895,0.00134149,0.01144592],"study_design_scores_gemma":[0.3630819,0.3554946,0.2112379,0.0003308814,0.04865101,0.0004349366,0.000277736,0.00771046,0.006632153,0.0006160053,0.005322614,0.0002098478],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891082,0.002740303,0.001330578,0.0003091503,0.0002457753,0.001964688,0.002038737,0.0001098775,0.002152654],"genre_scores_gemma":[0.9940373,0.0003461899,0.0008545131,0.0002647148,0.0001536838,0.001903902,0.001371789,0.00004725921,0.001020663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01872742,"threshold_uncertainty_score":0.09904128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02321968617977879,"score_gpt":0.3238871291431201,"score_spread":0.3006674429633413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}