{"id":"W4388522939","doi":"10.1016/j.xgen.2023.100439","title":"Synthetic chromosome fusion: Effects on mitotic and meiotic genome structure and function","year":2023,"lang":"en","type":"article","venue":"Cell Genomics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Council; Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University; National University of Singapore; Tianjin University; Tsinghua University; March of Dimes Foundation; Macquarie University; National Science Foundation; Imperial College London; National Institute of General Medical Sciences; Engineering Research Centers; York University; Johns Hopkins University; National Institutes of Health","keywords":"Centromere; Chromosome; Genetics; Chromosome segregation; Biology; Saccharomyces cerevisiae; Meiosis; Genome; Mitosis; Computational biology; Yeast; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003784872,0.000425349,0.0001961007,0.0002108559,0.0001369692,0.0002514036,0.0002532146,0.0003336994,0.001815984],"category_scores_gemma":[0.0003274044,0.0001833683,0.0002097523,0.0002453217,0.0002371552,0.000183035,0.0002541894,0.0004214234,0.0002742473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003425353,"about_ca_system_score_gemma":0.0001875546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003639011,"about_ca_topic_score_gemma":0.0005238546,"domain_scores_codex":[0.9997907,0.00003347672,0.00002545016,0.0000580991,0.00006060741,0.00003149985],"domain_scores_gemma":[0.9997073,0.00008351096,0.0001049961,0.0000298268,0.00002667491,0.00004769196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007306627,0.00001404215,0.00007239589,0.00003192172,0.000004237029,0.00003255284,0.00001227891,0.0002565889,0.9983349,0.0001923264,0.00001500418,0.0009605489],"study_design_scores_gemma":[0.00001228505,0.000207214,0.0007217381,0.000002345204,0.00001094273,0.000109542,0.00001121092,0.0005874092,0.9962112,0.00003812468,0.002082621,0.000005445134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810603,0.0009297287,0.01430354,0.00008514954,0.00003830995,0.00008212674,0.0006837081,0.0001564906,0.002660697],"genre_scores_gemma":[0.9867603,0.000613243,0.008708759,0.00004398308,0.000006966006,0.00004983014,0.001219649,0.0001336653,0.002463713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001815984,"threshold_uncertainty_score":0.006075025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003120108556577636,"score_gpt":0.1750052823702837,"score_spread":0.1718851738137061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}