{"id":"W4388522939","doi":"10.1016/j.xgen.2023.100439","title":"Synthetic chromosome fusion: Effects on mitotic and meiotic genome structure and function","year":2023,"lang":"en","type":"article","venue":"Cell Genomics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Research Council; Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University; National University of Singapore; Tianjin University; Tsinghua University; March of Dimes Foundation; Macquarie University; National Science Foundation; Imperial College London; National Institute of General Medical Sciences; Engineering Research Centers; York University; Johns Hopkins University; National Institutes of Health","keywords":"Centromere; Chromosome; Genetics; Chromosome segregation; Biology; Saccharomyces cerevisiae; Meiosis; Genome; Mitosis; Computational biology; Yeast; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008692383,0.0002078781,0.0001654124,0.00006844867,0.0001433673,0.00004943747,0.0001063641,0.0001852345,0.000009637241],"category_scores_gemma":[0.00001807344,0.0002048263,0.0000434123,0.00008654679,0.00006049496,0.000002357571,0.0001779397,0.0001025668,0.00002781114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002559139,"about_ca_system_score_gemma":0.00003306536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002005592,"about_ca_topic_score_gemma":0.000005208348,"domain_scores_codex":[0.9990279,0.00003413274,0.0001516489,0.0004490951,0.00007610086,0.0002611422],"domain_scores_gemma":[0.9994323,0.00002945684,0.00006516669,0.000336469,0.00002157392,0.0001150111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003357161,0.00001334455,0.0002520388,0.0001463955,0.00002829881,0.000007595689,0.0000775118,0.0006696278,0.9965333,0.00004798622,0.0001234774,0.00206689],"study_design_scores_gemma":[0.005806453,0.004857645,0.1446728,0.0001353768,0.000568273,0.0003830716,0.0006579358,0.02148636,0.7519398,0.005822487,0.06078107,0.00288874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997785,0.0012123,0.00009740812,0.00008630558,0.0003267859,0.0002408845,0.00003253364,0.00002530352,0.0001934366],"genre_scores_gemma":[0.9974239,0.001129618,0.0002691009,0.0002055445,0.0002669117,0.000007095,0.0001850138,0.00004713817,0.0004656232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2445934,"threshold_uncertainty_score":0.8352572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003120108556577636,"score_gpt":0.1750052823702837,"score_spread":0.1718851738137061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}