{"id":"W4388523685","doi":"10.26481/dis.20231024mf","title":"Features of muscle-specific tyrosine kinase autoantibodies and b cells derived from myasthenia gravis patients","year":2023,"lang":"en","type":"dissertation","venue":"","topic":"Myasthenia Gravis and Thymoma","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; Universiteit Maastricht; National Institute for Health and Care Research; European Academy of Neurology; York University; Pharmaceutical Research and Manufacturers of America Foundation; Wellcome Trust; Muscular Dystrophy Association; Myasthenia Gravis Foundation of America; Grifols; Alexander S. Onassis Public Benefit Foundation; Yale University","keywords":"Autoantibody; Rituximab; Myasthenia gravis; Immunology; Autoimmunity; B cell; Immune system; Medicine; Monoclonal; Syk; Autoimmune disease; Monoclonal antibody; Antibody; Tyrosine kinase; Internal medicine; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009184296,0.000159266,0.0001452332,0.0004614538,0.000251417,0.0003158696,0.0001061848,0.0002124322,0.003256188],"category_scores_gemma":[0.0002358011,0.00007980258,0.0001781366,0.0002347286,0.0001005583,0.0001376661,0.0001653309,0.0002537174,0.0008371454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002215243,"about_ca_system_score_gemma":0.0001490161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006866748,"about_ca_topic_score_gemma":0.0007366289,"domain_scores_codex":[0.9999511,0.000005810274,0.000003985004,0.00001119477,0.00001532005,0.00001259058],"domain_scores_gemma":[0.9999429,0.000009179312,0.00001216604,0.000002869084,0.0000147377,0.00001815255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002203207,0.0009105388,0.3346106,0.0006707828,0.0001142647,0.0606056,0.006024488,0.0003286313,0.423447,0.002469293,0.01088816,0.1577274],"study_design_scores_gemma":[0.00008620143,0.001316012,0.8471017,0.0001196168,0.00008371655,0.09094412,0.001942355,0.0001777223,0.02303842,0.0007092245,0.03446262,0.0000180999],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887467,0.0015798,0.0001580124,0.0002316889,0.00002341848,0.00003583674,0.0002606434,0.00001453089,0.008949404],"genre_scores_gemma":[0.9886608,0.001439692,0.0002434691,0.0002057239,0.00003316105,0.00002246491,0.0003568734,0.000008354136,0.009029397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003256188,"threshold_uncertainty_score":0.01089311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01194073915457962,"score_gpt":0.2486936211762732,"score_spread":0.2367528820216936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}