{"id":"W4388523859","doi":"10.1186/s41687-023-00650-3","title":"Psychometric validation of the Pyruvate Kinase Deficiency Diary and Pyruvate Kinase Deficiency Impact Assessment in adults in the phase 3 ACTIVATE trial","year":2023,"lang":"en","type":"article","venue":"Journal of Patient-Reported Outcomes","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"Agios Pharmaceuticals","keywords":"Convergent validity; Medicine; Population; Pyruvate kinase deficiency; Intraclass correlation; Pyruvate kinase; Clinical psychology; Internal medicine; Psychometrics; Internal consistency","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00181706,0.0002395698,0.0006581525,0.001283975,0.00009350345,0.0000217906,0.0001840093,0.0001180514,0.00004246466],"category_scores_gemma":[0.001848712,0.0001220797,0.0003421675,0.002883467,0.0001050815,0.0002188008,0.00005713945,0.0006214879,0.00000224257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000157437,"about_ca_system_score_gemma":0.0003434001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001122138,"about_ca_topic_score_gemma":0.00001239074,"domain_scores_codex":[0.9965653,0.0004288871,0.001611785,0.0002537035,0.0008029587,0.0003373763],"domain_scores_gemma":[0.9970545,0.0005339679,0.001661168,0.0004064573,0.0002347492,0.000109165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01160122,0.003023735,0.9438671,0.0001462363,0.00008753224,0.0003407267,0.002626031,0.0004420438,0.0248478,0.00002625954,0.000267449,0.0127238],"study_design_scores_gemma":[0.04077647,0.003389939,0.950997,0.0002702503,0.0001275676,0.00008245142,0.001484426,0.0002137816,0.002252338,0.0002270816,0.00004269271,0.0001360046],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996758,0.0001658195,0.0000261159,0.0008402221,0.001177904,0.0008686873,0.00001081418,0.00001403694,0.0001383465],"genre_scores_gemma":[0.9993162,0.0002723087,0.00004686762,0.0002270621,0.00006374788,0.00001863127,0.00001826607,0.00001705191,0.00001986149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02917526,"threshold_uncertainty_score":0.4978264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03463463812000153,"score_gpt":0.3584684582347126,"score_spread":0.3238338201147111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}