{"id":"W4388523918","doi":"10.2196/50733","title":"Genomic, Proteomic, and Phenotypic Biomarkers of COVID-19 Severity: Protocol for a Retrospective Observational Study","year":2023,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"SARS-CoV-2 detection and testing","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Mental Health; National Institute of Child Health and Human Development; NIHR Maudsley Biomedical Research Centre; Branch Out Neurological Foundation; Instituto de Salud Carlos III; Siemens Healthineers; Gratama Stichting; Universitair Medisch Centrum Groningen; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Ministero dell’Istruzione, dell’Università e della Ricerca; National Institutes of Health; GGZ inGeest; University of California, San Francisco; Rivierduinen; Ministero della Salute; Vrije Universiteit Amsterdam; National Alliance for Research on Schizophrenia and Depression; ZonMw; Alberta Children's Hospital Foundation; Klingenstein Third Generation Foundation; Universiteit Leiden; King's College London; Department for the Economy; Amsterdam University Medical Centers; Generalitat de Catalunya; European Regional Development Fund; National Healthcare Group; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Science Foundation Ireland; University of Minnesota; EU Joint Programme – Neurodegenerative Disease Research; National Health and Medical Research Council; Ege Üniversitesi; Public Health Agency; National Institute of Mental Health; Children's Hospital Foundation; Ministerio de Ciencia e Innovación; American Foundation for Suicide Prevention; Universitätsmedizin Göttingen; Medical Research Council; Leids Universitair Medisch Centrum; Department of Health and Social Care; University of Texas MD Anderson Cancer Center; Brain and Behavior Research Foundation","keywords":"Medicine; Cohort study; Retrospective cohort study; Cohort; Observational study; Intensive care medicine; Immunology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02484437,0.003801104,0.004226943,0.002930614,0.003742116,0.001979464,0.002590155,0.003578124,0.02613026],"category_scores_gemma":[0.0187362,0.00231779,0.002477271,0.00359015,0.002296079,0.002622102,0.001896468,0.003296789,0.01021442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003548915,"about_ca_system_score_gemma":0.01387859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00467719,"about_ca_topic_score_gemma":0.00431082,"domain_scores_codex":[0.9885082,0.005844489,0.002355557,0.001341495,0.001119331,0.000830901],"domain_scores_gemma":[0.9866756,0.002041131,0.002301203,0.002889916,0.004730803,0.001361345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.3007551,0.05132977,0.1315495,0.0513581,0.003222698,0.008722279,0.006090192,0.01811327,0.02492462,0.02368129,0.192394,0.187859],"study_design_scores_gemma":[0.1376743,0.08064572,0.2547268,0.02235577,0.001462899,0.003286235,0.004943023,0.01140173,0.007710499,0.01533532,0.4591241,0.00133368],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.004159678,0.000348729,0.005296107,0.000206568,0.0001685464,0.9831834,0.005236395,0.00006855299,0.001332136],"genre_scores_gemma":[0.004374062,0.0002004425,0.004613579,0.0002188959,0.00004830792,0.9888579,0.001378231,0.000008379846,0.0003002583],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02613026,"threshold_uncertainty_score":0.1313912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.556494646697397,"score_gpt":0.5866387117050602,"score_spread":0.0301440650076632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}