{"id":"W4388527196","doi":"10.1007/s12257-023-0077-5","title":"Design, Synthesis, In Silico Screening, and Antiproliferative Activity of Novel 1,2,3-Triazole Tethered Dibenzosuberane Conjugates","year":2023,"lang":"en","type":"article","venue":"Biotechnology and Bioprocess Engineering","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Tellabs (Canada)","funders":"","keywords":"Chemistry; In silico; Triazole; Stereochemistry; MTT assay; Docking (animal); Combinatorial chemistry; Conjugate; Nuclear magnetic resonance spectroscopy; Cytotoxicity; Molecular model; Proton NMR; In vitro; 1,2,3-Triazole; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001059137,0.0001456528,0.0002239891,0.0001023623,0.00005219275,0.00001049337,0.000109068,0.0003453358,0.000008472776],"category_scores_gemma":[0.0001576683,0.000144275,0.00001704262,0.0003513586,0.00013255,0.00005198806,0.00007576338,0.0002148025,5.564509e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007414172,"about_ca_system_score_gemma":0.00001071975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001739788,"about_ca_topic_score_gemma":0.000002903224,"domain_scores_codex":[0.9993305,0.000002500036,0.0001586548,0.0002657988,0.00005156341,0.0001909559],"domain_scores_gemma":[0.9995432,0.0002043932,0.00005849096,0.0001431166,0.00001744258,0.00003328641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000301789,0.00004828572,0.0008252996,0.0002671682,0.00002439916,0.00000246905,0.00005692805,0.0003362952,0.9943428,0.0001793784,0.000002507101,0.003884309],"study_design_scores_gemma":[0.0003921793,0.000008581549,0.0007310249,0.0001279265,0.00001052237,0.00001452698,0.0000904331,0.0278731,0.9704602,0.00003226802,0.0001128682,0.000146345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941179,0.0003576097,0.004550895,0.0006076546,0.000006052556,0.00007158137,0.00003367157,0.0002283097,0.00002634299],"genre_scores_gemma":[0.9984188,0.0003822693,0.001070934,0.000003516506,0.00001391333,0.00006479113,0.000005239431,0.00001317382,0.00002732911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02753681,"threshold_uncertainty_score":0.5883363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414899455948562,"score_gpt":0.2439820505313432,"score_spread":0.2198330559718576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}