{"id":"W4388527196","doi":"10.1007/s12257-023-0077-5","title":"Design, Synthesis, In Silico Screening, and Antiproliferative Activity of Novel 1,2,3-Triazole Tethered Dibenzosuberane Conjugates","year":2023,"lang":"en","type":"article","venue":"Biotechnology and Bioprocess Engineering","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Tellabs (Canada)","funders":"","keywords":"Chemistry; In silico; Triazole; Stereochemistry; MTT assay; Docking (animal); Combinatorial chemistry; Conjugate; Nuclear magnetic resonance spectroscopy; Cytotoxicity; Molecular model; Proton NMR; In vitro; 1,2,3-Triazole; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002063009,0.0003432214,0.0003131793,0.0002378001,0.0001279233,0.0003122361,0.0003902205,0.0003791579,0.0011623],"category_scores_gemma":[0.0001825641,0.0002036331,0.000205167,0.0002043336,0.0001311483,0.0001700531,0.0001550474,0.0003615459,0.0004049404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003780309,"about_ca_system_score_gemma":0.0002570522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004376996,"about_ca_topic_score_gemma":0.001576545,"domain_scores_codex":[0.9998792,0.00002218928,0.000009111885,0.00002512093,0.00004115574,0.00002321198],"domain_scores_gemma":[0.9999299,0.00001084287,0.0000222354,0.000006530025,0.00001383895,0.00001655261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000110462,0.00008444458,0.0001815399,0.00007950648,0.00001019166,0.00008630948,0.00001636574,0.00109205,0.9942123,0.0001677499,0.0000688647,0.003890199],"study_design_scores_gemma":[0.00006217902,0.001168954,0.0006675836,0.000006220812,0.00003753469,0.0001873032,0.000009639632,0.002752732,0.9916881,0.00002818023,0.003381696,0.000009808052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802918,0.002474422,0.01293628,0.0001823305,0.00003482228,0.0002686116,0.000548243,0.0002518134,0.003011655],"genre_scores_gemma":[0.9816858,0.001444749,0.01193692,0.0000715091,0.000008951268,0.00008094261,0.000719658,0.00002273557,0.004028758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0011623,"threshold_uncertainty_score":0.003888249,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414899455948562,"score_gpt":0.2439820505313432,"score_spread":0.2198330559718576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}