{"id":"W4388537448","doi":"10.1097/tp.0000000000004822","title":"Chronic Active Antibody-mediated Rejection: Opportunity to Determine the Role of Interleukin-6 Blockade","year":2023,"lang":"en","type":"review","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Canadian Transplant Association","funders":"Cedars-Sinai Medical Center; CSL Behring","keywords":"Medicine; Blockade; Clinical trial; Transplantation; Kidney transplantation; Immunology; Monoclonal antibody; Surrogate endpoint; Antibody; Intensive care medicine; Renal function; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001493379,0.0003798119,0.001132876,0.0003573931,0.00008580009,0.00001499576,0.0001629223,0.0002146215,0.0001545348],"category_scores_gemma":[0.00003643771,0.0002413042,0.000447614,0.0006882885,0.0000528305,0.00007020095,0.000009525578,0.0003244518,0.0002039887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001848436,"about_ca_system_score_gemma":0.0005296014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000144659,"about_ca_topic_score_gemma":0.0001160559,"domain_scores_codex":[0.9981374,0.0001394494,0.0007537,0.0003536969,0.0003653863,0.0002503562],"domain_scores_gemma":[0.9985678,0.0004434757,0.0003329433,0.0003310668,0.00009450716,0.0002302661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00037183,0.0001188645,0.00009294836,0.03673511,0.001254978,0.0003048801,0.001029754,0.000006923859,0.0005629428,0.00005496223,0.000007808573,0.959459],"study_design_scores_gemma":[0.009137983,0.00412748,0.006979569,0.2823435,0.0406389,0.003991103,0.0005815119,0.0001431499,0.008910522,0.0001460848,0.6411248,0.001875331],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001527588,0.9886804,0.0004564858,0.0001686985,0.0005094282,0.004435562,0.002011422,0.0002580504,0.001952419],"genre_scores_gemma":[0.001873378,0.9926217,0.00009443067,0.0000392822,0.0001948801,0.0001828832,0.004426999,0.00007051455,0.0004959959],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9575837,"threshold_uncertainty_score":0.98401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07339172644846831,"score_gpt":0.3797066546523322,"score_spread":0.3063149282038639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}