{"id":"W4388537448","doi":"10.1097/tp.0000000000004822","title":"Chronic Active Antibody-mediated Rejection: Opportunity to Determine the Role of Interleukin-6 Blockade","year":2023,"lang":"en","type":"review","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Canadian Transplant Association","funders":"Cedars-Sinai Medical Center; CSL Behring","keywords":"Medicine; Blockade; Clinical trial; Transplantation; Kidney transplantation; Immunology; Monoclonal antibody; Surrogate endpoint; Antibody; Intensive care medicine; Renal function; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001639051,0.0005587555,0.00181522,0.001605735,0.0002199028,0.001210237,0.0007479374,0.001189791,0.003461696],"category_scores_gemma":[0.001712425,0.0002033316,0.001060391,0.001117895,0.0004856928,0.001745299,0.0005639712,0.003176294,0.001036005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006777931,"about_ca_system_score_gemma":0.001434856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001080563,"about_ca_topic_score_gemma":0.00243308,"domain_scores_codex":[0.9996331,0.0001173926,0.00005360721,0.00004515235,0.0001207677,0.000030019],"domain_scores_gemma":[0.9989491,0.0006733093,0.0001046073,0.00002143153,0.0002015672,0.00005004273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001373851,0.00007935148,0.0001992453,0.01923844,0.0002405317,0.0001037235,0.00006600702,0.0001914065,0.0007639921,0.00561098,0.03525561,0.9381134],"study_design_scores_gemma":[0.00009299698,0.0002156439,0.0009121214,0.01912777,0.0004544634,0.0007967881,0.0001065747,0.0001053203,0.0002809396,0.00355678,0.9743279,0.00002259676],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000526613,0.9985644,0.00004450163,0.0007538791,0.0001823934,0.000002218105,0.000006694966,0.000002570165,0.0003906138],"genre_scores_gemma":[0.0006304324,0.9979264,0.0001218721,0.0008682992,0.0002348984,0.000006206019,0.00001562263,0.000001421257,0.0001948573],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003461696,"threshold_uncertainty_score":0.01158053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07339172644846831,"score_gpt":0.3797066546523322,"score_spread":0.3063149282038639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}