{"id":"W4388537572","doi":"10.2147/ijn.s427350","title":"A Macrophages-Enriched Head and Neck Tumor Spheroid Model to Study Foslip® Behavior in Tumor Microenvironment","year":2023,"lang":"en","type":"article","venue":"International Journal of Nanomedicine","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Institut de Cancérologie de Lorraine","keywords":"Tumor microenvironment; Head and neck squamous-cell carcinoma; Stromal cell; Flow cytometry; Spheroid; Macrophage; Cancer research; Cancer cell; Immune system; Cell culture; Cytotoxic T cell; Cancer; Biology; Chemistry; Cell biology; Immunology; In vitro; Head and neck cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001784176,0.0003966139,0.0003097949,0.0002614826,0.000190726,0.0001819605,0.0001552097,0.0003899535,0.0007590779],"category_scores_gemma":[0.00005291856,0.0001370809,0.0003126725,0.0001803553,0.0002117916,0.0001965028,0.000182471,0.0004032683,0.0003147544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004946681,"about_ca_system_score_gemma":0.0003512624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001755441,"about_ca_topic_score_gemma":0.002505044,"domain_scores_codex":[0.9998722,0.00001665519,0.000009138816,0.00003776849,0.000043545,0.00002061616],"domain_scores_gemma":[0.9999243,0.00001425049,0.00002071078,0.00001089786,0.00001403705,0.0000156866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000623689,0.00003827968,0.0002272598,0.00003887778,0.00000393027,0.00008868011,0.00002636379,0.0002539605,0.9985819,0.00006024214,0.00005793236,0.000560254],"study_design_scores_gemma":[0.00002001085,0.0004962432,0.003907984,0.000008275325,0.00002577391,0.0004323368,0.00005062158,0.005163523,0.9867815,0.00003957149,0.003064926,0.000009232954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823664,0.001658152,0.01325568,0.0001151756,0.00005953501,0.0001830673,0.0009598884,0.000157063,0.001245093],"genre_scores_gemma":[0.9818119,0.001040308,0.01308215,0.00005490588,0.00001297836,0.0002647617,0.0009708806,0.00002548345,0.002736606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001755441,"threshold_uncertainty_score":0.003589153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01841358362373411,"score_gpt":0.300417351818878,"score_spread":0.2820037681951438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}