{"id":"W4388538144","doi":"10.1111/dom.15353","title":"Effects of <scp>CB1R</scp> inverse agonist, <scp>INV</scp> ‐202, in patients with features of metabolic syndrome. A randomized, placebo‐controlled, double‐blind phase 1b study","year":2023,"lang":"en","type":"article","venue":"Diabetes Obesity and Metabolism","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Inversago Pharma (Canada)","funders":"American Diabetes Association","keywords":"Placebo; Medicine; Tolerability; Waist; Internal medicine; Gastroenterology; Confidence interval; Pharmacodynamics; Area under the curve; Body mass index; Metabolic syndrome; Adverse effect; Pharmacokinetics; Endocrinology; Obesity; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009008916,0.001069568,0.001897233,0.0002724527,0.000273663,0.0004351954,0.0004541009,0.001113654,0.003194771],"category_scores_gemma":[0.0006313117,0.000578894,0.001083108,0.0002263044,0.0005240094,0.0004557206,0.0002012161,0.001416647,0.0004743109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00029912,"about_ca_system_score_gemma":0.0006463348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006211193,"about_ca_topic_score_gemma":0.001801228,"domain_scores_codex":[0.9996946,0.0001562355,0.00002546881,0.00004904568,0.00003494813,0.00003978657],"domain_scores_gemma":[0.9995337,0.0001118799,0.0001064826,0.00002691712,0.00003678456,0.0001842638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9383154,0.01262998,0.002064727,0.0007450894,0.0009224154,0.0001297304,0.00005322256,0.0002933842,0.02196727,0.00004760786,0.0005103456,0.02232095],"study_design_scores_gemma":[0.7361278,0.2483732,0.0110851,0.00003281953,0.0007991127,0.0001444988,0.00004023496,0.0006728241,0.001988829,0.00005695095,0.0006537964,0.00002494691],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995389,0.002520409,0.0002510254,0.0001481125,0.0001028846,0.0006139548,0.0003117256,0.00003933235,0.0006235947],"genre_scores_gemma":[0.9952168,0.00148346,0.0007022249,0.000456922,0.000181153,0.0006501655,0.0004788658,0.000008999745,0.0008214251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003194771,"threshold_uncertainty_score":0.01068759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008409374410353864,"score_gpt":0.2591078960781044,"score_spread":0.2506985216677505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}