{"id":"W4388538178","doi":"10.1101/2023.11.08.566198","title":"Evolutionary constraint genes implicated in autism spectrum disorder across 2,054 nonhuman primate genomes","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Genome Canada","funders":"Medical Research Council; National Institutes of Health","keywords":"Macaque; Autism spectrum disorder; Rhesus macaque; Gene; Genome; Autism; Phenotype; Biology; Copy-number variation; Genetics; Genomics; Neurodevelopmental disorder; Constraint (computer-aided design); Computational biology; Neuroscience; Psychology; Developmental psychology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005650002,0.0003879979,0.0006861894,0.003305909,0.001130125,0.0008406847,0.0003866601,0.0004627339,0.002862389],"category_scores_gemma":[0.001393337,0.000234209,0.0007999525,0.003356425,0.0004169962,0.0002332299,0.0009076172,0.000470874,0.0003195714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003202308,"about_ca_system_score_gemma":0.0004060409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004715576,"about_ca_topic_score_gemma":0.008414509,"domain_scores_codex":[0.9993881,0.0001125649,0.0000402439,0.000287893,0.0001047732,0.00006642918],"domain_scores_gemma":[0.9993086,0.0003262659,0.0001652385,0.00008346541,0.00004651392,0.00007001892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00248876,0.0001705628,0.5115592,0.00130038,0.003621625,0.004144491,0.004088207,0.006573268,0.3868574,0.002973706,0.00394919,0.07227325],"study_design_scores_gemma":[0.00005792805,0.0001505424,0.9670191,0.0001217036,0.0006754554,0.00304423,0.0006957067,0.004900611,0.004545139,0.00146807,0.01727821,0.00004333152],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913272,0.0009307524,0.001178908,0.00006889489,0.000007588668,0.00001187095,0.005479715,0.0001002722,0.0008948227],"genre_scores_gemma":[0.9758089,0.0006082924,0.006993481,0.0001325115,0.00001670023,0.00008029922,0.01578876,0.00009933235,0.000471744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004715576,"threshold_uncertainty_score":0.009575665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03312417506085585,"score_gpt":0.2925636140454091,"score_spread":0.2594394389845533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}