{"id":"W4388540852","doi":"10.1016/j.cmet.2023.10.014","title":"Stress-induced β cell early senescence confers protection against type 1 diabetes","year":2023,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"JDRF; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Walloon excellence in life sciences and biotechnology; National Institutes of Health; Canadian Institutes of Health Research; Children's Hospital Research Institute of Manitoba; Innovative Medicines Initiative; Diabetes Fonds; Fonds De La Recherche Scientifique - FNRS; College of Engineering, University of Wisconsin-Madison; European Commission; Greater Milwaukee Foundation; European Federation of Pharmaceutical Industries and Associations; University of Manitoba; Juvenile Diabetes Research Foundation United States of America; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Senescence; Biology; Inflammation; Unfolded protein response; Cell biology; Islet; Immune system; Insulitis; Autoimmunity; Immunology; Cancer research; NOD mice; Cell; Cell type; Phenotype; Diabetes mellitus; Gene; Genetics; Endocrinology; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001849802,0.0002668048,0.0002469899,0.0002185386,0.00009907712,0.0002594492,0.0001135939,0.0001874139,0.001265006],"category_scores_gemma":[0.0001279508,0.00007290424,0.0002159819,0.0001117583,0.0001599482,0.00016156,0.0001847048,0.0005719616,0.0002695956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006645156,"about_ca_system_score_gemma":0.0001148723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009375672,"about_ca_topic_score_gemma":0.0001168851,"domain_scores_codex":[0.9999349,0.00001497757,0.000006584218,0.00001430931,0.00001038588,0.00001887971],"domain_scores_gemma":[0.999887,0.00001078794,0.00002951806,0.00001679926,0.000009572826,0.00004631141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001032755,0.0001026032,0.0009268754,0.00004216724,0.00001102801,0.00005711052,0.00001903983,0.00003335792,0.9920712,0.00006536915,0.00006236254,0.005576006],"study_design_scores_gemma":[0.000192145,0.008633193,0.1007915,0.00005046455,0.0001030106,0.001662656,0.0001284108,0.0006496598,0.8780251,0.0005732058,0.009172272,0.00001832527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956398,0.001977797,0.001055922,0.0001616545,0.00005195496,0.00001005141,0.0001260199,0.00006842291,0.0009082769],"genre_scores_gemma":[0.9963619,0.001656903,0.0006727799,0.0001068831,0.00004247581,0.000009321945,0.0001568243,0.00001379614,0.0009790809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001265006,"threshold_uncertainty_score":0.00423193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02698170980559217,"score_gpt":0.2397268553943533,"score_spread":0.2127451455887611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}