{"id":"W4388541037","doi":"10.1038/s41588-023-01534-4","title":"Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants","year":2023,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Toronto; Princess Margaret Cancer Centre","funders":"Common Fund; Division of Cancer Epidemiology and Genetics, National Cancer Institute; DOD Prostate Cancer Research Program; Hellenic Health Foundation; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; Ellison Medical Foundation; Instituto de Salud Carlos III; World Cancer Research Fund; Prostate Cancer Foundation; Medical Research Council; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Health and Human Services; University of California, San Francisco; National Institute for Health and Care Research; Vlaamse regering; Novo Nordisk Fonden; Fondation de France; National Health and Medical Research Council; Universiti Malaya; Prostate Cancer Foundation of Australia; Vetenskapsrådet; National Institute of Mental Health; KU Leuven; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Cancerfonden; Breast Cancer Research Foundation; University of Cambridge; U.S. Department of Defense; Cancer Research UK; Australian Government; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Swedish Cancer Foundation; Deutsches Krebsforschungszentrum; Associazione Italiana per la Ricerca sul Cancro; National Center for Advancing Translational Sciences; Kaiser Permanente; Fondation ARC pour la Recherche sur le Cancer; National Cancer Research Institute; Royal Marsden NHS Foundation Trust; European Commission; Cancer Council Victoria; Deutsche Krebshilfe; Office of Research and Development; National Institute on Aging; Wayne and Gladys Valley Foundation; Institut National Du Cancer; Cancer Research Institute; National Institutes of Health; Robert Wood Johnson Foundation","keywords":"Prostate cancer; Biology; Genome-wide association study; Disease; Genetic genealogy; Genetics; Genetic association; 1000 Genomes Project; Cancer; Ancestry-informative marker; Prostate; Single-nucleotide polymorphism; Oncology; Genotype; Internal medicine; Gene; Medicine; Population; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004360628,0.0002590746,0.0003443692,0.0000585751,0.0001604191,0.00002360487,0.0003213791,0.000681536,0.000007860057],"category_scores_gemma":[0.0006023796,0.0002418876,0.000158225,0.0003187789,0.0001089899,0.000008590424,0.0002415417,0.0004993422,0.00001183838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002815942,"about_ca_system_score_gemma":0.0001606296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001037201,"about_ca_topic_score_gemma":0.0001324692,"domain_scores_codex":[0.9981645,0.0001245445,0.0004658346,0.0005642733,0.0001797345,0.0005011004],"domain_scores_gemma":[0.9985805,0.00006714267,0.0005786082,0.0005319452,0.0001761769,0.00006569176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000433444,0.00009002081,0.7621732,0.00003653508,0.0002532678,0.000001899673,0.0003015835,0.003639722,0.2310541,0.000004695122,0.0009068261,0.001494729],"study_design_scores_gemma":[0.0007576183,0.0001165512,0.9474479,0.00001888572,0.00009647343,0.000002417329,0.0001454968,0.0006078021,0.03692126,0.0001202413,0.01347968,0.0002857171],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876229,0.004653275,0.004726732,0.0002128904,0.0007195256,0.0002994536,0.001645886,0.00002597149,0.0000934178],"genre_scores_gemma":[0.9565709,0.03112925,0.0100916,0.0004066089,0.000402233,0.00005014925,0.0004936627,0.00004893926,0.0008066235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1941329,"threshold_uncertainty_score":0.9863888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0196149227915922,"score_gpt":0.3005560051023191,"score_spread":0.2809410823107268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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