{"id":"W4388541037","doi":"10.1038/s41588-023-01534-4","title":"Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants","year":2023,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Toronto; Princess Margaret Cancer Centre","funders":"Common Fund; Division of Cancer Epidemiology and Genetics, National Cancer Institute; DOD Prostate Cancer Research Program; Hellenic Health Foundation; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Cancer Institute; Ellison Medical Foundation; Instituto de Salud Carlos III; World Cancer Research Fund; Prostate Cancer Foundation; Medical Research Council; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Health and Human Services; University of California, San Francisco; National Institute for Health and Care Research; Vlaamse regering; Novo Nordisk Fonden; Fondation de France; National Health and Medical Research Council; Universiti Malaya; Prostate Cancer Foundation of Australia; Vetenskapsrådet; National Institute of Mental Health; KU Leuven; Canadian Institutes of Health Research; Fonds Wetenschappelijk Onderzoek; Cancerfonden; Breast Cancer Research Foundation; University of Cambridge; U.S. Department of Defense; Cancer Research UK; Australian Government; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Swedish Cancer Foundation; Deutsches Krebsforschungszentrum; Associazione Italiana per la Ricerca sul Cancro; National Center for Advancing Translational Sciences; Kaiser Permanente; Fondation ARC pour la Recherche sur le Cancer; National Cancer Research Institute; Royal Marsden NHS Foundation Trust; European Commission; Cancer Council Victoria; Deutsche Krebshilfe; Office of Research and Development; National Institute on Aging; Wayne and Gladys Valley Foundation; Institut National Du Cancer; Cancer Research Institute; National Institutes of Health; Robert Wood Johnson Foundation","keywords":"Prostate cancer; Biology; Genome-wide association study; Disease; Genetic genealogy; Genetics; Genetic association; 1000 Genomes Project; Cancer; Ancestry-informative marker; Prostate; Single-nucleotide polymorphism; Oncology; Genotype; Internal medicine; Gene; Medicine; Population; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006307786,0.0002583264,0.0003266905,0.0008016363,0.0003446828,0.0004340295,0.0002329143,0.00030344,0.000808292],"category_scores_gemma":[0.001698751,0.0001817276,0.0004652037,0.0009000791,0.0002482038,0.0001541411,0.0005438679,0.0004444728,0.0001007256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001329038,"about_ca_system_score_gemma":0.0001637864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001899881,"about_ca_topic_score_gemma":0.003216139,"domain_scores_codex":[0.9995401,0.0001301863,0.00003430837,0.0001623048,0.00008159921,0.00005151485],"domain_scores_gemma":[0.9992492,0.0002439308,0.0002969352,0.0001120034,0.00003616976,0.00006169542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004569508,0.00004533066,0.9436431,0.00005612053,0.0007467383,0.0005659498,0.0004132809,0.0006923184,0.03716793,0.0002260812,0.000158236,0.0158279],"study_design_scores_gemma":[0.00003187378,0.0001094008,0.9933432,0.00001226778,0.0002616422,0.001173547,0.00008622203,0.0009358799,0.003174423,0.0002295941,0.000631485,0.00001042051],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985373,0.0002390295,0.0008793896,0.00002796126,0.000002697858,0.000005865712,0.0001761121,0.000008579837,0.0001230809],"genre_scores_gemma":[0.9987953,0.00008278715,0.0008826171,0.00001407761,0.000004469673,0.000003253223,0.0001474929,0.000004088387,0.00006586817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001899881,"threshold_uncertainty_score":0.003777683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0196149227915922,"score_gpt":0.3005560051023191,"score_spread":0.2809410823107268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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