{"id":"W4388550972","doi":"10.1002/pro.4824","title":"Engineered antigen‐binding fragments for enhanced crystallization of antibody:antigen complexes","year":2023,"lang":"en","type":"article","venue":"Protein Science","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Amgen (Canada); Lunenfeld-Tanenbaum Research Institute; University of Toronto; University of Waterloo","funders":"National Institute of General Medical Sciences; Bristol-Myers Squibb","keywords":"Crystallization; Antigen; Chemistry; Crystallography; Antibody; Immunoglobulin Fab Fragments; Epitope; Computational biology; Biology; Immunoglobulin light chain; Genetics; Complementarity determining region","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004526797,0.0003186776,0.000380263,0.0002429299,0.00013868,0.0002511727,0.0003701723,0.0002430594,0.0006279928],"category_scores_gemma":[0.0004253269,0.0001420305,0.0002292541,0.0003030664,0.0001774293,0.0001571445,0.0003187921,0.0005897333,0.0001905942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000301914,"about_ca_system_score_gemma":0.0002752007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006881941,"about_ca_topic_score_gemma":0.001593463,"domain_scores_codex":[0.9997663,0.00005867577,0.00002110727,0.00002647278,0.00008762982,0.00003983255],"domain_scores_gemma":[0.9999026,0.00002915081,0.00002188056,0.00001170222,0.00001925923,0.00001529159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005004886,0.00003895201,0.0002046754,0.00001797892,0.000009251543,0.00004519865,0.00002805247,0.0009044146,0.996739,0.0001979259,0.00003840059,0.001726087],"study_design_scores_gemma":[0.00002229404,0.0001508606,0.0008498902,0.000003407617,0.00001431249,0.000129791,0.0000110279,0.005267626,0.9920092,0.00005647743,0.001479325,0.000005702843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9728779,0.0005363974,0.0253555,0.00009416549,0.00001333144,0.00007561057,0.0001532121,0.0001140555,0.0007798413],"genre_scores_gemma":[0.9766291,0.0003284149,0.02190859,0.00006104737,0.000005275021,0.0000361503,0.0002555652,0.00005381917,0.0007220237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006881941,"threshold_uncertainty_score":0.002394021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04981586182818315,"score_gpt":0.3832515563490085,"score_spread":0.3334356945208254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}