{"id":"W4388550972","doi":"10.1002/pro.4824","title":"Engineered antigen‐binding fragments for enhanced crystallization of antibody:antigen complexes","year":2023,"lang":"en","type":"article","venue":"Protein Science","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Amgen (Canada); Lunenfeld-Tanenbaum Research Institute; University of Toronto; University of Waterloo","funders":"National Institute of General Medical Sciences; Bristol-Myers Squibb","keywords":"Crystallization; Antigen; Chemistry; Crystallography; Antibody; Immunoglobulin Fab Fragments; Epitope; Computational biology; Biology; Immunoglobulin light chain; Genetics; Complementarity determining region","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007813636,0.0001106455,0.0002207974,0.0003529337,0.0002538071,0.00003541906,0.0002932482,0.00003943576,0.00007243802],"category_scores_gemma":[0.0003088258,0.00009156413,0.00006150311,0.001293697,0.0003442301,0.0002423082,0.0001018743,0.00007322285,0.0000346319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002902468,"about_ca_system_score_gemma":0.0002064321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004225952,"about_ca_topic_score_gemma":0.000002540768,"domain_scores_codex":[0.9981804,0.00001850558,0.0002560614,0.0003398703,0.0007537582,0.0004513824],"domain_scores_gemma":[0.9991395,0.00004931923,0.00007780324,0.0002220934,0.0003459658,0.0001653427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009619815,0.00005559019,0.002771086,0.0001942637,0.00001083084,0.000002854029,0.0002748402,0.00004842311,0.9933503,0.001086768,0.00002610796,0.002082762],"study_design_scores_gemma":[0.0004221571,0.0003367331,0.03226194,0.000172416,0.000004056198,0.000002642664,0.0001053413,0.00832889,0.9568431,0.0003666953,0.001049618,0.0001064652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9812047,0.00004919013,0.01668906,0.0002205589,0.00007772839,0.001151131,0.00004120257,0.00007208424,0.0004942759],"genre_scores_gemma":[0.9907051,0.00007458151,0.007688574,0.0000231381,0.00006900655,0.00006112256,0.0001128628,0.00001365058,0.001252006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03650723,"threshold_uncertainty_score":0.3733877,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04981586182818315,"score_gpt":0.3832515563490085,"score_spread":0.3334356945208254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}