{"id":"W4388552676","doi":"10.2139/ssrn.4626869","title":"Immunogenicity of SARSCoV2 Third Dose Vaccine Strategies in Immunocompromised Patients with Suboptimal Immunity Following Two Doses (OCTAVE-DUO): An Open-Label, Multi-Centre, Randomised, Controlled Phase III Trial","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Medicine; Immunogenicity; Vaccination; Antibody; Internal medicine; Immunity; Randomized controlled trial; Clinical trial; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001520508,0.001480973,0.003554964,0.0002998006,0.0003584043,0.001424948,0.0007834488,0.00210045,0.004542182],"category_scores_gemma":[0.001155165,0.0005362299,0.001924274,0.0003639655,0.001250215,0.001171225,0.000418567,0.00295659,0.0009964192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007642384,"about_ca_system_score_gemma":0.0009409111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006178875,"about_ca_topic_score_gemma":0.0008592075,"domain_scores_codex":[0.999397,0.0002788385,0.00003524773,0.0001042219,0.00004326949,0.0001413945],"domain_scores_gemma":[0.9992344,0.0001819771,0.0001645983,0.00007342918,0.00004840869,0.0002971328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9703879,0.00782432,0.0006895483,0.0003571718,0.0006369668,0.0000359459,0.00006491865,0.0003141371,0.002984181,0.00009376769,0.0004154503,0.01619577],"study_design_scores_gemma":[0.8123604,0.1831093,0.002390991,0.00004604694,0.0003275693,0.00004229189,0.00003733257,0.0004102248,0.0004990755,0.0001870854,0.0005704834,0.00001915857],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994412,0.002350305,0.0003796011,0.0003239113,0.0002248385,0.001196704,0.0003326816,0.0000396388,0.0007402971],"genre_scores_gemma":[0.9913834,0.001682332,0.0009254912,0.0007803093,0.0002629196,0.002086161,0.0007803495,0.00001802312,0.00208094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004542182,"threshold_uncertainty_score":0.01519507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04830311392577744,"score_gpt":0.3814467307111946,"score_spread":0.3331436167854172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}