{"id":"W4388556935","doi":"10.3389/fonc.2023.1249453","title":"Case Report: Prolonged remission of metastatic cisplatin-refractory nasopharyngeal carcinoma with Pembrolizumab","year":2023,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster Children's Hospital; McMaster University; London Health Sciences Centre; Western University","funders":"","keywords":"Medicine; Pembrolizumab; Oncology; Nasopharyngeal carcinoma; Internal medicine; Gemcitabine; Chemotherapy; Cancer; Radiation therapy; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000404178,0.001432374,0.001378739,0.001425687,0.002724621,0.001377859,0.001392179,0.005718799,0.002321611],"category_scores_gemma":[0.002199153,0.0008226528,0.00124863,0.001307632,0.001212165,0.001651976,0.001251028,0.00410524,0.001048553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001559904,"about_ca_system_score_gemma":0.001218967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002330759,"about_ca_topic_score_gemma":0.003815338,"domain_scores_codex":[0.999383,0.00006596219,0.00006029369,0.0001696344,0.0000996788,0.0002214016],"domain_scores_gemma":[0.9987075,0.0002506671,0.0003200124,0.0002089759,0.00008403882,0.0004287862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00006378019,0.0000409542,0.002920541,0.00003254847,0.00001237379,0.9940467,0.0001085063,0.00007446526,0.0005681334,0.0001451284,0.0003301786,0.001656746],"study_design_scores_gemma":[0.0000224212,0.00006020941,0.002324872,0.00001028237,0.00001195216,0.996165,0.00004392266,0.0001919865,0.0002933386,0.0000973615,0.0007726519,0.000005983348],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9542839,0.01154548,0.006980228,0.006140357,0.0007967254,0.0003942084,0.0005627947,0.0003519284,0.01894431],"genre_scores_gemma":[0.9922512,0.001693644,0.001402888,0.001279489,0.0007395817,0.00006525437,0.0001864279,0.00003135436,0.002350058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005718799,"threshold_uncertainty_score":0.01131791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03628475099710817,"score_gpt":0.3316437064476222,"score_spread":0.295358955450514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}