{"id":"W4388557321","doi":"10.1038/s42003-023-05513-7","title":"Variations of intronic branchpoint motif: identification and functional implications in splicing and disease","year":2023,"lang":"en","type":"review","venue":"Communications Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"RNA splicing; Intron; Motif (music); Exon; Biology; Genetics; Alternative splicing; Gene; Computational biology; Sequence motif; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004359633,0.0001630897,0.0004073918,0.0002934758,0.0001573246,0.00002248064,0.0003929137,0.0002005188,0.000004041112],"category_scores_gemma":[0.0006221257,0.0001576396,0.00008891284,0.000327059,0.0003288978,0.000006768176,0.0006892135,0.0002260527,0.000007623214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003431831,"about_ca_system_score_gemma":0.000324322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005447884,"about_ca_topic_score_gemma":0.0001937417,"domain_scores_codex":[0.9985151,0.0003202882,0.000567982,0.0003659462,0.00004285395,0.0001878343],"domain_scores_gemma":[0.9980038,0.0002375703,0.0002468908,0.001305525,0.00009252715,0.0001136753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002633711,0.0002477153,0.00403372,0.004054398,0.0003881434,4.393857e-7,0.0000572727,0.00001274401,0.01245744,0.1191213,0.0004204793,0.85918],"study_design_scores_gemma":[0.001147149,0.0002342282,0.05561483,0.003345753,0.0007269767,0.00005511777,0.0001010262,0.001598995,0.00004586058,0.01806717,0.9179913,0.001071611],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001314542,0.9949619,0.002094651,0.0006868348,0.00003590556,0.0006114331,0.0002265176,0.0000140991,0.00005410089],"genre_scores_gemma":[0.01046153,0.9858883,0.0002991455,0.00002053456,0.00004104189,0.000407308,0.002532103,0.00002527273,0.0003247725],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9175708,"threshold_uncertainty_score":0.6428356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08670728566787095,"score_gpt":0.3881671295852439,"score_spread":0.3014598439173729,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}