{"id":"W4388562165","doi":"10.1101/2023.11.09.23298321","title":"Concurrent RB1 loss and <i>BRCA</i> -deficiency predicts enhanced immunological response and long-term survival in tubo-ovarian high-grade serous carcinoma","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; Alberta Health Services; University of British Columbia; Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency; Foothills Medical Centre; University of Alberta; University of Calgary","funders":"Medical Research and Materiel Command; National Center for Advancing Translational Sciences; BC Cancer Foundation; Cancer Institute NSW; National Cancer Institute; University College London; National Health and Medical Research Council; University of Cambridge; Cancer Research UK; Michael Smith Health Research BC; National Institute for Health and Care Research; National Institutes of Health; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Oak Foundation; Medical Research Council; Swedish Cancer Foundation; European Commission; Cedars-Sinai Medical Center; Marshfield Clinic Research Foundation","keywords":"Ovarian cancer; Ovarian carcinoma; Serous fluid; Germline; Serous carcinoma; Biology; Cancer research; Oncology; Cancer; Internal medicine; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002751275,0.0001227991,0.0002000749,0.0004324573,0.0002331696,0.0003870292,0.0001598552,0.0001727261,0.001197762],"category_scores_gemma":[0.0006978,0.0001004865,0.0002000369,0.0004484056,0.0002294597,0.0001410293,0.0002135283,0.0001768844,0.000117544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001767515,"about_ca_system_score_gemma":0.0001338803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001346435,"about_ca_topic_score_gemma":0.00155207,"domain_scores_codex":[0.9998857,0.00002420053,0.00001713234,0.00003083901,0.00001886885,0.00002330567],"domain_scores_gemma":[0.9994448,0.0001303334,0.0002241135,0.00006177068,0.00004667028,0.00009228334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002580273,0.000009961905,0.9935839,0.00001208408,0.00002572402,0.0001684887,0.00002170057,0.00005745591,0.004705208,0.000007361114,0.00003774737,0.001112333],"study_design_scores_gemma":[0.000006543253,0.00007888956,0.9968298,0.000002993309,0.00004070079,0.001293644,0.00007364109,0.0002130699,0.001259548,0.00001986703,0.0001797669,0.000001499434],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996116,0.0001310016,0.00005895722,0.00000648288,9.722302e-7,0.000002148723,0.00008775892,0.000002647056,0.00009855085],"genre_scores_gemma":[0.9997805,0.00003037409,0.00003994606,0.000004107257,0.000001764499,0.000001638133,0.0001049453,8.015315e-7,0.0000358752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001346435,"threshold_uncertainty_score":0.004006863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03971792290788793,"score_gpt":0.2964053709764137,"score_spread":0.2566874480685258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}