{"id":"W4388563672","doi":"10.1021/acs.bioconjchem.3c00449","title":"BASHY Dyes Are Highly Efficient Lipid Droplet-Targeting Photosensitizers that Induce Ferroptosis through Lipid Peroxidation","year":2023,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Agència Valenciana de la Innovació; Fonds de recherche du Québec – Nature et technologies; Fundação para a Ciência e a Tecnologia; Fonds de Recherche du Québec - Santé; Ministerio de Ciencia e Innovación; Smithsonian Conservation Biology Institute; Junta de Andalucía; Natural Sciences and Engineering Research Council of Canada; Universidade de Lisboa; Universidad de Huelva; Agence Nationale de la Recherche; H2020 European Research Council; Universidad de Málaga; China Scholarship Council; Canada Foundation for Innovation; École Normale Supérieure","keywords":"Phototoxicity; Chemistry; Lipid peroxidation; Photodynamic therapy; Singlet oxygen; In vivo; Reactive oxygen species; Intracellular; Biochemistry; Cell culture; Biophysics; Photosensitizer; Pharmacology; In vitro; Oxidative stress; Photochemistry; Oxygen; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001358616,0.0002802802,0.0001457017,0.0001801011,0.00009469774,0.0001338991,0.0001158333,0.0002385936,0.0006855894],"category_scores_gemma":[0.0000995926,0.0000920397,0.0001069378,0.0001021871,0.0001463214,0.0001799868,0.0001563284,0.000256751,0.0001899149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001632541,"about_ca_system_score_gemma":0.00009044557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003812861,"about_ca_topic_score_gemma":0.0007861371,"domain_scores_codex":[0.9999248,0.00001801287,0.000003988271,0.00001345583,0.00002536905,0.00001437394],"domain_scores_gemma":[0.9999349,0.00001460835,0.00002548706,0.000003953804,0.00001237708,0.000008583598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001615253,0.000003423105,0.00005878888,0.00002997915,0.000002071392,0.00001997646,0.000004680837,0.00005032202,0.9985403,0.00006532081,0.00002001003,0.001189102],"study_design_scores_gemma":[0.000003447566,0.00008573785,0.000406266,0.000001926526,0.000003310989,0.000122553,0.000006306722,0.0002550546,0.9979971,0.00001878028,0.001097311,0.000002149552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9704937,0.004201706,0.021822,0.0001631893,0.00002878941,0.00005804772,0.0001839579,0.0001518932,0.002896729],"genre_scores_gemma":[0.9887345,0.001505407,0.007614597,0.00005072574,0.000007281391,0.00001565082,0.0001074863,0.0000140689,0.00195014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006855894,"threshold_uncertainty_score":0.002293587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198975201045576,"score_gpt":0.2675940908711817,"score_spread":0.2356043388607259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}