{"id":"W4388563672","doi":"10.1021/acs.bioconjchem.3c00449","title":"BASHY Dyes Are Highly Efficient Lipid Droplet-Targeting Photosensitizers that Induce Ferroptosis through Lipid Peroxidation","year":2023,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Ferroptosis and cancer prognosis","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Agència Valenciana de la Innovació; Fonds de recherche du Québec – Nature et technologies; Fundação para a Ciência e a Tecnologia; Fonds de Recherche du Québec - Santé; Ministerio de Ciencia e Innovación; Smithsonian Conservation Biology Institute; Junta de Andalucía; Natural Sciences and Engineering Research Council of Canada; Universidade de Lisboa; Universidad de Huelva; Agence Nationale de la Recherche; H2020 European Research Council; Universidad de Málaga; China Scholarship Council; Canada Foundation for Innovation; École Normale Supérieure","keywords":"Phototoxicity; Chemistry; Lipid peroxidation; Photodynamic therapy; Singlet oxygen; In vivo; Reactive oxygen species; Intracellular; Biochemistry; Cell culture; Biophysics; Photosensitizer; Pharmacology; In vitro; Oxidative stress; Photochemistry; Oxygen; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003376455,0.0004748775,0.0006031306,0.00008224589,0.0003027527,0.0001237831,0.0002188295,0.0003564615,0.0005357472],"category_scores_gemma":[0.0001833857,0.0004398836,0.0003093499,0.0007409604,0.0001785247,0.0001155184,0.0001737791,0.0004214498,0.0003302727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002828111,"about_ca_system_score_gemma":0.0001433652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000831231,"about_ca_topic_score_gemma":0.000001343539,"domain_scores_codex":[0.9971142,0.0000469959,0.0005109411,0.0009012179,0.0006727922,0.0007538403],"domain_scores_gemma":[0.9984932,0.00007880684,0.0003150172,0.0006107065,0.0002207928,0.0002814587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001901314,0.0001834891,0.004837992,0.0007939243,0.0001337492,0.00004321941,0.000769073,0.00004313215,0.9753571,0.000009497403,0.01679672,0.0008420057],"study_design_scores_gemma":[0.001322543,0.00008352825,0.002581763,0.0005154454,0.0001558124,0.0000235618,0.004123853,0.0007109958,0.9693918,0.000005452886,0.02058662,0.0004986393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907944,0.0002679737,0.00002023391,0.004002884,0.0005213746,0.0005346392,0.00007198774,0.0006463464,0.003140133],"genre_scores_gemma":[0.9952052,0.0005996181,0.0002828647,0.0008999066,0.001095558,0.0001870073,0.0004770911,0.0001044554,0.001148282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005965284,"threshold_uncertainty_score":0.9998053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03198975201045576,"score_gpt":0.2675940908711817,"score_spread":0.2356043388607259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}