{"id":"W4388567714","doi":"10.3390/biomedicines11113017","title":"The Ultraviolet Irradiation of Keratinocytes Induces Ectopic Expression of LINE-1 Retrotransposon Machinery and Leads to Cellular Senescence","year":2023,"lang":"en","type":"article","venue":"Biomedicines","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Cancer Research Society","keywords":"HaCaT; Genome instability; Ectopic expression; Retrotransposon; Senescence; Keratinocyte; Downregulation and upregulation; Biology; DNA damage; Cell culture; Photoaging; Cell biology; Molecular biology; Transfection; Cancer research; Genetics; DNA; Gene; Transposable element","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001346699,0.0002751062,0.0002559937,0.0002638449,0.0001451968,0.0002809946,0.0001182008,0.000236522,0.001465063],"category_scores_gemma":[0.0001046047,0.0001895572,0.0003814188,0.0002052457,0.0001342587,0.0001578036,0.0001611764,0.0004964654,0.0005428215],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002041301,"about_ca_system_score_gemma":0.0001293509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002971834,"about_ca_topic_score_gemma":0.0003470003,"domain_scores_codex":[0.9997904,0.00003275853,0.00002641113,0.00004599085,0.00006749955,0.00003696875],"domain_scores_gemma":[0.9998952,0.0000188911,0.0000290472,0.00002301507,0.00001699211,0.00001675289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004032601,0.00002018283,0.0002002333,0.00002423628,0.000004392457,0.00003782516,0.00001450499,0.00001340933,0.998966,0.00002039048,0.00002287378,0.0006356559],"study_design_scores_gemma":[0.000005852105,0.000229479,0.009621248,0.000009612645,0.00001315161,0.0003536446,0.00003543865,0.000362135,0.9873698,0.00003834764,0.001955431,0.000005723409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874594,0.00480583,0.00428404,0.00007614907,0.00008674779,0.00006347499,0.0006671617,0.0001635105,0.002393716],"genre_scores_gemma":[0.9891334,0.002356379,0.003197143,0.00008316097,0.00001519514,0.00008249193,0.0009061112,0.00002571278,0.004200354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001465063,"threshold_uncertainty_score":0.004901111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01940367474269891,"score_gpt":0.2371733102034743,"score_spread":0.2177696354607754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}