{"id":"W4388570445","doi":"10.1016/j.jaad.2023.11.005","title":"Orismilast in moderate-to-severe psoriasis: Efficacy and safety from a 16-week, randomized, double-blinded, placebo-controlled, dose-finding, and phase 2b trial (IASOS)","year":2023,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health; Queen's University; Dalhousie University","funders":"Manchester Biomedical Research Centre; LEO Pharma; Simon Spies Fonden; Novo Nordisk Fonden; National Institute for Health and Care Research; Sanofi Genzyme; Incyte; Mylan; Horizon Therapeutics; Sun Pharma; Regeneron Pharmaceuticals; Sanofi; Galderma; Bristol-Myers Squibb; Eli Lilly and Company; Samsung; National Psoriasis Foundation; Galápagos; Meiji Seika Pharma; Pfizer; Amgen","keywords":"Medicine; Placebo; Double blinded; Psoriasis; Randomized controlled trial; Physical therapy; Surgery; Dermatology; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005588431,0.0001979307,0.001103138,0.0002436966,0.00008744167,0.00002155372,0.0002138634,0.0001778365,0.000007745411],"category_scores_gemma":[0.0002849595,0.0001324355,0.0002097102,0.0002850329,0.0003612328,0.0000153281,0.0001382415,0.0003221914,0.000001920707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000226278,"about_ca_system_score_gemma":0.00006857928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003292388,"about_ca_topic_score_gemma":0.00001067445,"domain_scores_codex":[0.9979178,0.0005135743,0.0009010023,0.0002401986,0.0001959134,0.0002315095],"domain_scores_gemma":[0.9983181,0.0003427182,0.00104193,0.0001209354,0.00004830873,0.0001279895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9803561,0.0001286436,0.0003863766,0.000008995872,0.0003677144,0.000007198355,0.000191613,0.0005432376,0.01463926,0.00004047304,0.001214404,0.002115965],"study_design_scores_gemma":[0.9837866,0.0004643607,0.001259244,0.0000628921,0.0002032684,0.0004603529,0.000270342,0.0005937098,0.009238515,0.0003076351,0.003169578,0.0001835012],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919636,0.0007035558,0.0004377215,0.005715291,0.0003221857,0.000787597,0.0000137174,0.00000607336,0.00005028093],"genre_scores_gemma":[0.9975128,0.00131649,0.0001505791,0.0006533731,0.0002233916,0.00002404338,0.000008666714,0.00001655417,0.00009411099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005549214,"threshold_uncertainty_score":0.5400563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02505260532906677,"score_gpt":0.3189194022564432,"score_spread":0.2938667969273764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}