{"id":"W4388570445","doi":"10.1016/j.jaad.2023.11.005","title":"Orismilast in moderate-to-severe psoriasis: Efficacy and safety from a 16-week, randomized, double-blinded, placebo-controlled, dose-finding, and phase 2b trial (IASOS)","year":2023,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health; Queen's University; Dalhousie University","funders":"Manchester Biomedical Research Centre; LEO Pharma; Simon Spies Fonden; Novo Nordisk Fonden; National Institute for Health and Care Research; Sanofi Genzyme; Incyte; Mylan; Horizon Therapeutics; Sun Pharma; Regeneron Pharmaceuticals; Sanofi; Galderma; Bristol-Myers Squibb; Eli Lilly and Company; Samsung; National Psoriasis Foundation; Galápagos; Meiji Seika Pharma; Pfizer; Amgen","keywords":"Medicine; Placebo; Double blinded; Psoriasis; Randomized controlled trial; Physical therapy; Surgery; Dermatology; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004243396,0.001525666,0.00298016,0.000450707,0.0004607243,0.001000234,0.0008713756,0.001671523,0.005663549],"category_scores_gemma":[0.00254188,0.000652847,0.002250821,0.0004994624,0.0009372074,0.0007845534,0.0005222293,0.00241083,0.0008036351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004718555,"about_ca_system_score_gemma":0.001355614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003888679,"about_ca_topic_score_gemma":0.001146136,"domain_scores_codex":[0.9989142,0.000582089,0.00007966239,0.0001898566,0.0001181092,0.0001159966],"domain_scores_gemma":[0.9986487,0.0002266397,0.0004003911,0.0001358894,0.0001219221,0.0004664923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9534162,0.009244272,0.001519758,0.001036552,0.00139781,0.00005232406,0.00009238525,0.0002654284,0.008191369,0.00008020387,0.001699986,0.02300349],"study_design_scores_gemma":[0.9407705,0.05386784,0.003679775,0.00004145958,0.0004570832,0.00005543124,0.00001143906,0.0001817057,0.0003233864,0.0000600925,0.0005388376,0.00001241475],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817472,0.006258963,0.0008994693,0.0009685606,0.0002841495,0.005594747,0.002123562,0.0002147281,0.001908455],"genre_scores_gemma":[0.9732128,0.004985313,0.003890614,0.002045497,0.0006999684,0.007677125,0.003571713,0.00006444117,0.003852373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005663549,"threshold_uncertainty_score":0.02244145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02505260532906677,"score_gpt":0.3189194022564432,"score_spread":0.2938667969273764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}