{"id":"W4388575014","doi":"10.1016/j.cgh.2023.10.029","title":"ENTERPRET: A Randomized Controlled Trial of Vedolizumab Dose Optimization in Patients With Ulcerative Colitis Who Have Early Nonresponse","year":2023,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Viropharma","keywords":"Vedolizumab; Medicine; Ulcerative colitis; Clinical endpoint; Dosing; Randomized controlled trial; Internal medicine; Adverse effect; Clinical trial; Intention-to-treat analysis; Gastroenterology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00181862,0.001269442,0.002289811,0.0005025791,0.0003729746,0.001097523,0.0007536677,0.001297976,0.007302557],"category_scores_gemma":[0.0022788,0.0005200987,0.001349596,0.0003440701,0.0007406655,0.001057853,0.0005042626,0.002233597,0.0005565844],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000536667,"about_ca_system_score_gemma":0.0008861784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005311164,"about_ca_topic_score_gemma":0.00126739,"domain_scores_codex":[0.9992793,0.000455035,0.00004043888,0.00009993649,0.00004982641,0.00007559035],"domain_scores_gemma":[0.9991942,0.0002905116,0.0002204913,0.00004984042,0.00005491132,0.0001900002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.983074,0.003762392,0.0003540661,0.0004994252,0.0005312518,0.00003937262,0.00002480061,0.0003105807,0.001483042,0.0001395715,0.0006772243,0.009104258],"study_design_scores_gemma":[0.9712301,0.02691683,0.0006219616,0.00003137671,0.0002093879,0.0000246992,0.00001205176,0.0002900234,0.0001466544,0.0000713721,0.0004377125,0.000007666121],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815804,0.005842998,0.0009649326,0.001041342,0.0008562692,0.004810932,0.001522896,0.0002052316,0.003174896],"genre_scores_gemma":[0.9772229,0.003169262,0.003248383,0.001363854,0.0005121662,0.007744846,0.001857536,0.00003720246,0.004843798],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007302557,"threshold_uncertainty_score":0.0244295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00873698419811549,"score_gpt":0.2792113556315101,"score_spread":0.2704743714333946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}