{"id":"W4388588374","doi":"10.1093/neuonc/noad179.0337","title":"CTNI-55. A MULTICENTER STUDY OF LOW-INTENSITY FOCUSED ULTRASOUND WITH SYSTEMIC MICROBUBBLE OSCILLATORS FOR BLOOD-BRAIN BARRIER DISRUPTION FOR LIQUID BIOPSY IN GLIOBLASTOMA (LIBERATE)","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Concordance; Biopsy; Liquid biopsy; Microbubbles; Blood sampling; Radiology; Ultrasound; Internal medicine; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00483159,0.002286662,0.00261114,0.0005493305,0.0006422887,0.001685792,0.001135712,0.001459386,0.002786434],"category_scores_gemma":[0.00230237,0.0007426912,0.002202729,0.0007277154,0.001648768,0.001025778,0.0006259609,0.002360241,0.001086926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001284864,"about_ca_system_score_gemma":0.002999264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001954188,"about_ca_topic_score_gemma":0.002739305,"domain_scores_codex":[0.9981981,0.0008621642,0.0001276074,0.0003805242,0.0001216597,0.0003101063],"domain_scores_gemma":[0.998109,0.0002178644,0.0004373802,0.0002457579,0.0001638742,0.0008261693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9204618,0.0251315,0.005864777,0.0005887941,0.002172648,0.0000935442,0.0001542916,0.000520927,0.01831345,0.0001817389,0.001091498,0.025425],"study_design_scores_gemma":[0.4293349,0.5489948,0.01325987,0.00005550567,0.002333548,0.0001411678,0.00005474085,0.0004167261,0.003304195,0.0001068884,0.001950053,0.00004764357],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887382,0.00457504,0.0008433783,0.000512207,0.0002688058,0.002848555,0.0008408145,0.00009347463,0.001279416],"genre_scores_gemma":[0.9843151,0.003084081,0.002326254,0.001124432,0.0005260402,0.004197037,0.002609987,0.00005346169,0.001763667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00483159,"threshold_uncertainty_score":0.02555221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126689143733392,"score_gpt":0.2481416315106366,"score_spread":0.2368747400733026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}