{"id":"W4388588374","doi":"10.1093/neuonc/noad179.0337","title":"CTNI-55. A MULTICENTER STUDY OF LOW-INTENSITY FOCUSED ULTRASOUND WITH SYSTEMIC MICROBUBBLE OSCILLATORS FOR BLOOD-BRAIN BARRIER DISRUPTION FOR LIQUID BIOPSY IN GLIOBLASTOMA (LIBERATE)","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Concordance; Biopsy; Liquid biopsy; Microbubbles; Blood sampling; Radiology; Ultrasound; Internal medicine; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002415599,0.000240587,0.0004929504,0.0002495133,0.0000946885,0.00002225289,0.0001855576,0.0001719865,0.000007309278],"category_scores_gemma":[0.000143989,0.000219511,0.00008696457,0.000485179,0.00006392065,0.00008901106,0.00002690348,0.0001685628,0.0000171297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001096914,"about_ca_system_score_gemma":0.00005721824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002717355,"about_ca_topic_score_gemma":0.0005166236,"domain_scores_codex":[0.9985445,0.00006475683,0.0004621568,0.000399624,0.0001075144,0.0004215051],"domain_scores_gemma":[0.9982876,0.001051536,0.000102837,0.0003206398,0.0001447617,0.00009263142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008902366,0.0003930913,0.003648687,0.0002130492,0.00009990248,0.00001508438,0.002803964,0.004471379,0.9868646,0.00002556301,0.0004360312,0.0001384698],"study_design_scores_gemma":[0.07176769,0.02855442,0.01471901,0.0006913026,0.001428162,0.001228307,0.02104111,0.04781282,0.780336,0.000236516,0.02902093,0.003163727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956973,0.00002341549,0.0008389343,0.0001267118,0.000292638,0.002590533,0.0001297679,0.0002674578,0.00003325428],"genre_scores_gemma":[0.9982514,0.0000118934,0.0003252655,0.00009473519,0.00008912087,0.001078599,0.00002729006,0.00008673164,0.00003493536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2065285,"threshold_uncertainty_score":0.8951399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126689143733392,"score_gpt":0.2481416315106366,"score_spread":0.2368747400733026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}