{"id":"W4388588379","doi":"10.1093/neuonc/noad179.1183","title":"MODL-32. EGFRVIII OVEREXPRESSION AND LOSS OF MOUSE SPECIFIC CDKN2A IN GLIAL CELLS LEADS TO GLIOMAGENESIS IN A NOVEL MOUSE MODEL","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Pathology; NeuN; OLIG2; Immunohistochemistry; Glioma; Biology; Cancer research; Glial fibrillary acidic protein; Medicine; Oligodendrocyte; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004646604,0.001545279,0.0005724121,0.002554696,0.0006252856,0.0006349776,0.0007723233,0.001220404,0.004301066],"category_scores_gemma":[0.0001365186,0.0006544948,0.0007552008,0.0005927068,0.0008347112,0.0005663073,0.0005067738,0.002063999,0.002141161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008979218,"about_ca_system_score_gemma":0.0006131779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001320485,"about_ca_topic_score_gemma":0.002547525,"domain_scores_codex":[0.9995244,0.00005590612,0.00005462189,0.0001190945,0.0001413753,0.0001046538],"domain_scores_gemma":[0.9996656,0.00003350172,0.0001174764,0.00004495338,0.00002725536,0.0001110981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004106679,0.0004831859,0.0002855839,0.00007287256,0.00001911338,0.0004199181,0.00006109857,0.000203984,0.9938866,0.001468054,0.0004421108,0.00224672],"study_design_scores_gemma":[0.000372451,0.001864495,0.002646961,0.00005061818,0.00005920941,0.002215489,0.00008925411,0.001995172,0.9752855,0.0004232941,0.0149769,0.00002060968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9620892,0.002403301,0.01748429,0.0009636777,0.0002659095,0.0009071616,0.006768468,0.001591432,0.00752646],"genre_scores_gemma":[0.9294198,0.003069356,0.02039064,0.0003268445,0.00006506607,0.001708647,0.006064043,0.0004096613,0.03854601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004301066,"threshold_uncertainty_score":0.0143885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0371716245391149,"score_gpt":0.303883359120198,"score_spread":0.2667117345810832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}