{"id":"W4388588426","doi":"10.1093/neuonc/noad179.0992","title":"RTID-01. A RANDOMIZED STUDY OF LOW-INTENSITY FOCUSED ULTRASOUND FOR BLOOD-BRAIN BARRIER DISRUPTION FOR BRAIN METASTASIS FROM NON-SMALL CELL LUNG CANCER (LIMITLESS)","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Pembrolizumab; Lung cancer; Clinical endpoint; Brain metastasis; Randomized controlled trial; Internal medicine; Oncology; Surgery; Cancer; Metastasis; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003251499,0.00179104,0.003241525,0.0005725793,0.0004431354,0.001614785,0.001069281,0.002275336,0.01036028],"category_scores_gemma":[0.003480198,0.0008441178,0.002369029,0.0004320185,0.001209947,0.001262608,0.0006650438,0.00272315,0.001401206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000851336,"about_ca_system_score_gemma":0.001334904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000684203,"about_ca_topic_score_gemma":0.00108778,"domain_scores_codex":[0.9981028,0.001139263,0.0001660834,0.0003056137,0.0001025036,0.0001837193],"domain_scores_gemma":[0.9983128,0.0005095365,0.0004326521,0.0001668708,0.0001279674,0.0004502916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9890187,0.003116261,0.000245671,0.0004933561,0.0006051658,0.0000154372,0.00001561389,0.00009430938,0.001145245,0.0001106428,0.0002918236,0.00484783],"study_design_scores_gemma":[0.950838,0.04727546,0.0004383575,0.00002721807,0.0004709353,0.00001344321,0.00001135835,0.0001823598,0.000212783,0.0000991995,0.0004222704,0.000008644255],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675915,0.007452755,0.001558978,0.001308387,0.001870752,0.01430852,0.002434095,0.0002354821,0.003239537],"genre_scores_gemma":[0.9668497,0.002395018,0.003526014,0.001822065,0.001087251,0.0167769,0.001673599,0.00004540284,0.005824016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01036028,"threshold_uncertainty_score":0.03465855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01823476246504585,"score_gpt":0.2784095334425079,"score_spread":0.260174770977462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}