{"id":"W4388588499","doi":"10.1093/neuonc/noad179.0556","title":"IMMU-24. SALVAGE IMMUNOTHERAPIES FOR REPLICATION REPAIR DEFICIENT (RRD) HIGH-GRADE GLIOMA FAILING ANTI-PD1 MONOTHERAPY: A REPORT FROM THE INTERNATIONAL RRD CONSORTIUM","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"","keywords":"Ipilimumab; Medicine; Internal medicine; Oncology; Expanded access; Nivolumab; Immune checkpoint; Progression-free survival; Progressive disease; Salvage therapy; Immunotherapy; Surgery; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004667164,0.0005318006,0.0005193041,0.0005816596,0.0002235696,0.0007051848,0.0004119922,0.000542524,0.0006169195],"category_scores_gemma":[0.002128307,0.0001090318,0.0006258762,0.0005838811,0.0003271218,0.000195349,0.0003267362,0.0005527844,0.0002651345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008127135,"about_ca_system_score_gemma":0.001388279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001620222,"about_ca_topic_score_gemma":0.001781666,"domain_scores_codex":[0.9987526,0.000613639,0.0001351093,0.0001498401,0.0002000878,0.0001486644],"domain_scores_gemma":[0.9984475,0.0004731611,0.0002940161,0.0001414931,0.0003808539,0.0002628951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01879403,0.003212965,0.08964891,0.002055607,0.001008865,0.002811871,0.0007652199,0.001165716,0.05999435,0.0008698874,0.01466353,0.8050091],"study_design_scores_gemma":[0.01193135,0.08074369,0.4887721,0.001586442,0.005476561,0.01562592,0.001234191,0.003631569,0.1713826,0.0006918919,0.2187102,0.0002135384],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8248755,0.1521738,0.002689132,0.003454171,0.0002249445,0.0008280584,0.002094201,0.0001550894,0.01350501],"genre_scores_gemma":[0.9551767,0.0325895,0.003135177,0.002566935,0.000237873,0.0005018182,0.003505353,0.000042207,0.002244415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004667164,"threshold_uncertainty_score":0.02468264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03714463828167817,"score_gpt":0.325559275956624,"score_spread":0.2884146376749458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}