{"id":"W4388588518","doi":"10.1093/neuonc/noad179.0978","title":"QOL-26. A RANDOMIZED, DOUBLE-BLIND PHASE 3 STUDY OF VORASIDENIB VS PLACEBO IN PATIENTS WITH MUTANT <i>IDH1/2</i>DIFFUSE GLIOMA (INDIGO): ANALYSIS OF HEALTH-RELATED QUALITY OF LIFE, NEUROCOGNITION AND SEIZURES","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Toronto General Hospital","funders":"","keywords":"Medicine; Placebo; Clinical endpoint; Quality of life (healthcare); Randomized controlled trial; Neurocognitive; Internal medicine; Physical therapy; Cognition; Psychiatry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001827858,0.001891221,0.002776151,0.0006311917,0.000409407,0.0009290201,0.0007555021,0.001244504,0.008398582],"category_scores_gemma":[0.001215581,0.0007851337,0.002541412,0.0004995005,0.001338448,0.0007678436,0.0003614556,0.002493107,0.0009529763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007581504,"about_ca_system_score_gemma":0.001453714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006682004,"about_ca_topic_score_gemma":0.001573693,"domain_scores_codex":[0.9993371,0.0003641571,0.00003521712,0.0001010567,0.0000522102,0.0001101819],"domain_scores_gemma":[0.9993981,0.0001398683,0.000184742,0.00003875687,0.00004078667,0.0001977753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9761958,0.00654277,0.0004381118,0.0006584138,0.0007289319,0.00002723793,0.0000293698,0.0004112744,0.003326249,0.000108971,0.00080338,0.01072942],"study_design_scores_gemma":[0.9475246,0.05008519,0.001131742,0.00001832194,0.0002299389,0.00001675628,0.000009320585,0.0002271045,0.0002773069,0.00008848887,0.0003812182,0.00000990953],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689047,0.007348072,0.001161958,0.0007819647,0.0007297772,0.013478,0.00384713,0.0002930342,0.003455352],"genre_scores_gemma":[0.971838,0.002922768,0.002237294,0.001018,0.000283408,0.01665051,0.00186966,0.0000359593,0.003144424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008398582,"threshold_uncertainty_score":0.02809608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04818460316316055,"score_gpt":0.3572831364768596,"score_spread":0.3090985333136991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}