{"id":"W4388588518","doi":"10.1093/neuonc/noad179.0978","title":"QOL-26. A RANDOMIZED, DOUBLE-BLIND PHASE 3 STUDY OF VORASIDENIB VS PLACEBO IN PATIENTS WITH MUTANT <i>IDH1/2</i>DIFFUSE GLIOMA (INDIGO): ANALYSIS OF HEALTH-RELATED QUALITY OF LIFE, NEUROCOGNITION AND SEIZURES","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Toronto General Hospital","funders":"","keywords":"Medicine; Placebo; Clinical endpoint; Quality of life (healthcare); Randomized controlled trial; Neurocognitive; Internal medicine; Physical therapy; Cognition; Psychiatry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001164532,0.0002785889,0.00301163,0.001656512,0.00005411181,0.000006832321,0.00009265897,0.0001524498,0.00002587291],"category_scores_gemma":[0.0006211687,0.0002104527,0.0002120348,0.002749112,0.0002352558,0.00006985529,0.00007900246,0.0002206338,0.000002033256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007625337,"about_ca_system_score_gemma":0.0002615729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001766405,"about_ca_topic_score_gemma":0.001164558,"domain_scores_codex":[0.9950342,0.001565471,0.001993991,0.0005319441,0.0005509548,0.000323467],"domain_scores_gemma":[0.9956892,0.001920856,0.001489366,0.0003986003,0.0003089165,0.0001931334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5523387,0.02313483,0.4084561,0.000212089,0.002449915,0.000359727,0.003759645,0.0002131868,0.00770025,0.00001470242,0.00003732779,0.0013236],"study_design_scores_gemma":[0.7174297,0.0105807,0.2655838,0.00005703613,0.002609867,0.00000921911,0.0006956772,0.0002947541,0.002605427,0.00001377949,0.000005861922,0.0001141388],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943498,0.0001199054,0.000002648677,0.000498828,0.00008488552,0.004791526,0.00007683138,0.00004600736,0.00002954202],"genre_scores_gemma":[0.9992692,0.00007990678,0.0000158295,0.0001444667,0.000008719197,0.0003117638,0.0001347244,0.00003429169,0.000001060011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.165091,"threshold_uncertainty_score":0.8582011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04818460316316055,"score_gpt":0.3572831364768596,"score_spread":0.3090985333136991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}