{"id":"W4388588556","doi":"10.1093/neuonc/noad179.0479","title":"EPCO-16. DISRUPTING DOT1L EPIGENETIC ACTIVITY REPROGRAMS GLIOBLASTOMA STEM CELLS TOWARDS A DOPAMINERGIC NEURONAL-LIKE STATE","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Neurosciences, Mental Health and Addiction; Government of Canada; University of Calgary","funders":"","keywords":"Epigenetics; Biology; Chromatin; Neural stem cell; Transcription factor; Stem cell; Epigenetic regulation of neurogenesis; Epigenomics; Embryonic stem cell; Gene silencing; Regulation of gene expression; Neuroscience; Gene expression; Genetics; Cancer research; Cell biology; DNA methylation; Chromatin remodeling; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000868327,0.0002666146,0.0002657614,0.000214492,0.0001340101,0.0002646059,0.0002014599,0.0002806987,0.002476983],"category_scores_gemma":[0.00007607403,0.0001088583,0.0001949748,0.0001945542,0.0001882006,0.0001106907,0.0001641903,0.0005728356,0.0007422988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002903745,"about_ca_system_score_gemma":0.0003072585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001157693,"about_ca_topic_score_gemma":0.002145903,"domain_scores_codex":[0.9998819,0.00001064425,0.00001641597,0.00002864763,0.00003218444,0.00003022661],"domain_scores_gemma":[0.9999118,0.00001124639,0.00002208087,0.0000122285,0.00001126181,0.00003149153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001679398,0.0000872837,0.0002812484,0.00004933312,0.0000061844,0.00004818922,0.00001454176,0.0000930652,0.9966537,0.0001066401,0.0001932185,0.002298544],"study_design_scores_gemma":[0.00003468397,0.00056252,0.004896505,0.00000765092,0.00001472577,0.0001379346,0.00002293247,0.000689715,0.9888672,0.00003271129,0.004729432,0.000004013223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908126,0.001355095,0.001942361,0.0001823259,0.00007079558,0.00007002172,0.002544205,0.0002053769,0.002817238],"genre_scores_gemma":[0.9850642,0.0007664136,0.001589657,0.0001351386,0.000007478169,0.0001092386,0.00400859,0.00004019053,0.008278909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002476983,"threshold_uncertainty_score":0.008286357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02129663654771561,"score_gpt":0.2954241088017304,"score_spread":0.2741274722540147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}