{"id":"W4388588572","doi":"10.1093/neuonc/noad179.0183","title":"CSIG-27. FLUID SHEAR STRESS ACTIVATES A MECHANO-METASTATIC CASCADE TO PROMOTE MEDULLOBLASTOMA METASTASIS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; SickKids Foundation","funders":"","keywords":"Metastasis; Cancer research; Cerebrospinal fluid; Cancer cell; Cell; Cell migration; Medulloblastoma; Chemistry; Medicine; Pathology; Cancer; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006158826,0.0002653421,0.0002031783,0.000128792,0.0001590382,0.0002461934,0.0001864598,0.0002317112,0.00287254],"category_scores_gemma":[0.00008851267,0.0001530692,0.0003560287,0.00009633749,0.0001935999,0.0001234922,0.0002027336,0.0003762702,0.0003027162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005464751,"about_ca_system_score_gemma":0.0005535244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003470656,"about_ca_topic_score_gemma":0.00382643,"domain_scores_codex":[0.9999536,0.000003959406,0.000001657809,0.000008056124,0.00001498353,0.00001768495],"domain_scores_gemma":[0.9999678,0.000003751265,0.000007091687,0.00000177557,0.000003322086,0.00001627572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003521673,0.0001295853,0.001893846,0.0001486607,0.00001970925,0.0002122249,0.00002029355,0.01852471,0.9715493,0.001210726,0.0008571732,0.005081694],"study_design_scores_gemma":[0.0002590261,0.001201676,0.01616444,0.00003904225,0.0000632597,0.0002633013,0.0001167165,0.2239539,0.743859,0.001178663,0.01285212,0.00004890373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875824,0.0006300308,0.005970487,0.0002213243,0.00007607682,0.00006071728,0.0007207196,0.0003140811,0.00442409],"genre_scores_gemma":[0.9961231,0.0003130361,0.001754437,0.00005392737,0.000003777827,0.00003622958,0.0003193612,0.00002569409,0.00137035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003470656,"threshold_uncertainty_score":0.00960958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01868003800446571,"score_gpt":0.2958610730525301,"score_spread":0.2771810350480644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}