{"id":"W4388588613","doi":"10.1093/neuonc/noad179.0030","title":"BIOM-19. PLASMA EXTRACELLULAR VESICLE SAMPLING FROM HIGH GRADE GLIOMA PATIENTS DEMONSTRATES A SMALL RNA SIGNATURE INDICATIVE OF DISEASE AND IDENTIFIES LNCRNA RPPH1 AS A HIGH GRADE GLIOMA BIOMARKER","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Nova Scotia Health Authority; Dalhousie University","funders":"","keywords":"Glioma; Paracrine signalling; microRNA; RNA; Biomarker; Cancer research; Biology; Extracellular vesicle; Messenger RNA; Transfer RNA; Small RNA; Microvesicles; Cell biology; Gene; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001037657,0.0002013882,0.0001682695,0.0004624113,0.0001917733,0.0003588297,0.0001103557,0.0002419602,0.001564782],"category_scores_gemma":[0.0002438138,0.00008655807,0.0001459513,0.0002537235,0.0001291549,0.0001000801,0.0002219799,0.0001866693,0.0003848798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001645489,"about_ca_system_score_gemma":0.0001113775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000932151,"about_ca_topic_score_gemma":0.001097294,"domain_scores_codex":[0.9998978,0.0000115281,0.00000976851,0.0000372925,0.00002383583,0.00001968239],"domain_scores_gemma":[0.9999239,0.00001383853,0.00002552556,0.000006559633,0.00001431333,0.00001588047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001945288,0.00008355881,0.3900508,0.000201378,0.0001057579,0.001552063,0.0002953225,0.0002968701,0.5729234,0.00014272,0.0006757185,0.03172733],"study_design_scores_gemma":[0.00002528551,0.0007387798,0.8780749,0.00002157618,0.00007791666,0.008088175,0.0003790686,0.001778238,0.1074603,0.0001627007,0.003177936,0.00001520435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971892,0.0004220924,0.0008235881,0.00003644004,0.000008526429,0.00001739303,0.0007869633,0.00004111934,0.0006745852],"genre_scores_gemma":[0.9975165,0.000120458,0.0008492953,0.00003398594,0.000004144985,0.00001439607,0.0009992669,0.000007602528,0.0004544152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001564782,"threshold_uncertainty_score":0.005234659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0203560994556298,"score_gpt":0.2751730821211275,"score_spread":0.2548169826654977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}