{"id":"W4388588716","doi":"10.1093/neuonc/noad179.0374","title":"DNAR-08. BASE EXCISION REPAIR AS A THERAPEUTIC TARGET FOR DIFFUSE HEMISPHERIC GLIOMA, H3.3G34-MUTANT","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research; Hospital for Sick Children","funders":"","keywords":"XRCC1; Base excision repair; DNA repair; Biology; Cancer research; Glioma; Nucleotide excision repair; Homologous recombination; ERCC1; Gene knockdown; Wild type; Mutant; Mutation; DNA mismatch repair; Molecular biology; Genetics; Apoptosis; DNA; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001155026,0.0002838295,0.000355157,0.0001670104,0.0001085835,0.0002046993,0.0002269808,0.0004034023,0.002527238],"category_scores_gemma":[0.00005309072,0.00009740087,0.0002314833,0.0001702504,0.0001522643,0.0001012808,0.0001414849,0.0005128437,0.0006767829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002459072,"about_ca_system_score_gemma":0.000202068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005296132,"about_ca_topic_score_gemma":0.0014821,"domain_scores_codex":[0.9999336,0.00000630402,0.00000446707,0.00001718818,0.00001906084,0.00001944636],"domain_scores_gemma":[0.9999589,0.000002927809,0.00001259856,0.000006054425,0.000004558059,0.00001500087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008560196,0.0002354415,0.001454107,0.0002361907,0.00004284067,0.0003578569,0.00002916614,0.0002316634,0.9785534,0.0002009853,0.0007627971,0.0170396],"study_design_scores_gemma":[0.0004557444,0.008848779,0.0316276,0.00002718346,0.0001553142,0.003666302,0.00007036316,0.001226785,0.9376394,0.0001655553,0.01610208,0.00001485279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899165,0.003533154,0.001326708,0.0002229065,0.000054895,0.0001270599,0.001306525,0.000334127,0.003178175],"genre_scores_gemma":[0.9914804,0.001020998,0.001736305,0.0001226457,0.00000814852,0.00006052762,0.001702944,0.000029214,0.003838907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002527238,"threshold_uncertainty_score":0.008454442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03162264533893572,"score_gpt":0.322488166151862,"score_spread":0.2908655208129263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}