{"id":"W4388588801","doi":"10.1093/neuonc/noad179.0333","title":"CTNI-51. A RANDOMIZED DOUBLE-BLIND PHASE 3 STUDY OF VORASIDENIB VS PLACEBO IN PATIENTS WITH MUTANT <i>IDH1</i>/<i>2</i> DIFFUSE GLIOMA (INDIGO): EXPLORATORY ANALYSIS OF VARIANT ALLELE FREQUENCY AND PROGRESSION-FREE SURVIVAL","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Toronto General Hospital","funders":"","keywords":"Medicine; IDH1; Internal medicine; Glioma; Placebo; Hazard ratio; Gastroenterology; Isocitrate dehydrogenase; Mucositis; Oligodendroglioma; Oncology; Interim analysis; Progression-free survival; Randomized controlled trial; Confidence interval; Astrocytoma; Pathology; Chemotherapy; Mutant; Biology; Genetics; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001658086,0.002030917,0.002898513,0.0006765737,0.000562438,0.001227932,0.001157239,0.002112824,0.01097063],"category_scores_gemma":[0.001625309,0.000968631,0.002019353,0.0006422012,0.001571597,0.001114042,0.0003401437,0.003774773,0.001773474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00109113,"about_ca_system_score_gemma":0.002089199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001303025,"about_ca_topic_score_gemma":0.004485032,"domain_scores_codex":[0.9993353,0.0003180224,0.00003757821,0.0001302566,0.00005136484,0.000127527],"domain_scores_gemma":[0.9993303,0.0001377387,0.0001653714,0.0000526632,0.00004424932,0.0002697576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.978662,0.005255049,0.0002471891,0.0005805569,0.0005138486,0.00002901678,0.00002923053,0.0003597481,0.003363415,0.000155165,0.001260144,0.009544579],"study_design_scores_gemma":[0.9614336,0.03661323,0.0005822478,0.00002211514,0.0002272749,0.00001869157,0.000008450876,0.00026482,0.000286374,0.0001170642,0.0004131246,0.00001306685],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9468367,0.01089464,0.001817091,0.001557169,0.002043284,0.01957658,0.00595615,0.0006487905,0.0106696],"genre_scores_gemma":[0.9699499,0.003343878,0.002268587,0.001709604,0.0004241526,0.01363227,0.00260858,0.00005253361,0.006010543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01097063,"threshold_uncertainty_score":0.03670037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02803217890194327,"score_gpt":0.3209197887098628,"score_spread":0.2928876098079195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}