{"id":"W4388588801","doi":"10.1093/neuonc/noad179.0333","title":"CTNI-51. A RANDOMIZED DOUBLE-BLIND PHASE 3 STUDY OF VORASIDENIB VS PLACEBO IN PATIENTS WITH MUTANT <i>IDH1</i>/<i>2</i> DIFFUSE GLIOMA (INDIGO): EXPLORATORY ANALYSIS OF VARIANT ALLELE FREQUENCY AND PROGRESSION-FREE SURVIVAL","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Toronto General Hospital","funders":"","keywords":"Medicine; IDH1; Internal medicine; Glioma; Placebo; Hazard ratio; Gastroenterology; Isocitrate dehydrogenase; Mucositis; Oligodendroglioma; Oncology; Interim analysis; Progression-free survival; Randomized controlled trial; Confidence interval; Astrocytoma; Pathology; Chemotherapy; Mutant; Biology; Genetics; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008977943,0.0003888201,0.002575485,0.001522606,0.00007367804,0.00001633123,0.0002252635,0.0001846407,0.00004022245],"category_scores_gemma":[0.0004511486,0.000268435,0.000213974,0.0026147,0.000273806,0.0001204994,0.0002080283,0.0002577907,0.000002991143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001160465,"about_ca_system_score_gemma":0.0002760216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002784426,"about_ca_topic_score_gemma":0.0008979776,"domain_scores_codex":[0.9959506,0.0008897233,0.001176494,0.0007222154,0.0008090396,0.0004518835],"domain_scores_gemma":[0.9964072,0.001508167,0.000711946,0.0008151364,0.0003020033,0.0002555276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5137709,0.03525792,0.4140169,0.00009528509,0.003859143,0.004753866,0.005274794,0.00005592554,0.02176628,0.00006235658,0.0001122083,0.0009744469],"study_design_scores_gemma":[0.9337059,0.01277947,0.04005706,0.0000745247,0.005433896,0.00001685392,0.00113435,0.0002400395,0.006256991,0.00004403794,0.00002856359,0.00022826],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993836,0.00011756,0.000005311616,0.000385482,0.0001614742,0.005281678,0.00006759969,0.0000585823,0.00008632727],"genre_scores_gemma":[0.9984049,0.00007059908,0.0001217314,0.00006574879,0.00002786021,0.001130063,0.0001292061,0.00004826182,0.000001587688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4199351,"threshold_uncertainty_score":0.9999768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02803217890194327,"score_gpt":0.3209197887098628,"score_spread":0.2928876098079195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}