{"id":"W4388588920","doi":"10.1093/neuonc/noad179.1198","title":"MODL-47. A NEW MOUSE MODEL OF IDH MUTATED GLIOMAS IDENTIFIES TUMOR CELLS OF ORIGIN AND DETERMINANTS OF SENSITIVITY TO IDH INHIBITORS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; McGill University; Hospital for Sick Children; Princess Margaret Cancer Centre","funders":"","keywords":"Biology; IDH1; Mutant; Cancer research; IDH2; Glioma; Tumor progression; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003169435,0.001110997,0.0005262854,0.002094072,0.0004152885,0.0006376411,0.0007791552,0.001245647,0.004193519],"category_scores_gemma":[0.000134028,0.0005879432,0.0007708839,0.0005230617,0.0008152573,0.0006283224,0.000453544,0.002594796,0.001464832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009862798,"about_ca_system_score_gemma":0.0005333743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188328,"about_ca_topic_score_gemma":0.00239482,"domain_scores_codex":[0.9993374,0.00005179591,0.00007645906,0.0001763349,0.0001914732,0.0001665704],"domain_scores_gemma":[0.9995199,0.00004023655,0.0001828603,0.00004647746,0.00003136783,0.0001790597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003066211,0.0001911743,0.0004613501,0.00006779219,0.00001526537,0.0002333246,0.00005017687,0.0001962513,0.995343,0.0008982397,0.0003133047,0.001923466],"study_design_scores_gemma":[0.00008461448,0.0005408284,0.003880971,0.00002907597,0.00004489232,0.0007259204,0.00007520171,0.001970281,0.9845078,0.0002325426,0.007892894,0.00001497579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663143,0.001579585,0.01624668,0.000774543,0.0001925638,0.0002434274,0.008268891,0.001198064,0.005181924],"genre_scores_gemma":[0.9464179,0.001594817,0.01775727,0.0003124202,0.00003889087,0.0006015874,0.006520813,0.0004238283,0.02633237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004193519,"threshold_uncertainty_score":0.01402873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03527107215231706,"score_gpt":0.3161033457505929,"score_spread":0.2808322735982758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}