{"id":"W4388588958","doi":"10.1093/neuonc/noad179.1159","title":"MODL-08. A COMPENDIUM OF SYNGENEIC, TRANSPLANTABLE PEDIATRIC HIGH-GRADE GLIOMA MODELS REVEALS SUBTYPE-SPECIFIC THERAPEUTIC VULNERABILITIES","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Montreal Children's Hospital; Jewish General Hospital","funders":"","keywords":"Biology; Cancer research; Histone H3; KRAS; Phenotype; Glioma; Mutation; Gene; Histone; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001253771,0.001086535,0.000606277,0.002049664,0.0005360502,0.0006432388,0.001455868,0.0007923801,0.004181837],"category_scores_gemma":[0.0002701557,0.0004942771,0.0005947911,0.0006268203,0.0003151571,0.0004545078,0.0006614642,0.001954781,0.003093716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006242587,"about_ca_system_score_gemma":0.0005801074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009162569,"about_ca_topic_score_gemma":0.002241927,"domain_scores_codex":[0.9994801,0.00007325389,0.00007069376,0.00006569368,0.0002093692,0.0001010387],"domain_scores_gemma":[0.9996617,0.00006113419,0.00006821768,0.0000873629,0.00005196354,0.00006975235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006149666,0.0006069765,0.0009534009,0.0003250066,0.00006231517,0.0002723708,0.0001107347,0.0010943,0.9562265,0.002352209,0.01169717,0.02568404],"study_design_scores_gemma":[0.0003544769,0.002601269,0.004859838,0.0001168876,0.0002080972,0.002196437,0.00008420624,0.005639791,0.8056294,0.0005690465,0.1776972,0.0000433157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6892474,0.0125883,0.1366767,0.003103776,0.0008970015,0.004798771,0.0948512,0.01084546,0.04699134],"genre_scores_gemma":[0.5884461,0.01444034,0.1399123,0.001365524,0.0001374075,0.00887768,0.1741744,0.003076497,0.06956981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004181837,"threshold_uncertainty_score":0.01398963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04947750444937658,"score_gpt":0.2942189613114304,"score_spread":0.2447414568620538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}