{"id":"W4388588967","doi":"10.1093/neuonc/noad179.0900","title":"EXTH-47. TUMOUR-TARGETED PAN-RAS INHIBITION AS A NOVEL THERAPY FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Chimera (genetics); Cancer research; Viability assay; Downregulation and upregulation; Glioma; Cell; Targeted therapy; Cell culture; Biology; Cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007398228,0.0002590194,0.0002885751,0.0001440325,0.00006944432,0.0002225513,0.0001945529,0.0002166996,0.001415054],"category_scores_gemma":[0.00003101196,0.00006944094,0.000212434,0.0001464645,0.0001576508,0.0001209268,0.0001247993,0.0005187871,0.0003167236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002258699,"about_ca_system_score_gemma":0.0002101334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006011612,"about_ca_topic_score_gemma":0.001118206,"domain_scores_codex":[0.9999475,0.000005472958,0.000002234611,0.000009992128,0.00001629809,0.00001838861],"domain_scores_gemma":[0.9999831,0.00000179976,0.000004101563,0.000002182837,0.000001757624,0.000007159144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000435033,0.000194897,0.0003403965,0.0002125548,0.00002300984,0.0002394632,0.00002146067,0.0003217846,0.9783545,0.0002871093,0.0002992979,0.01927049],"study_design_scores_gemma":[0.0001617681,0.005737052,0.005556944,0.00001930811,0.00005979749,0.001441371,0.0000282305,0.0008566854,0.9765879,0.00008333655,0.009458844,0.000008605145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851708,0.008209916,0.002270921,0.0001946726,0.00005385475,0.0001031007,0.0005239574,0.0002105059,0.003262272],"genre_scores_gemma":[0.9923669,0.002946944,0.001278182,0.00005819952,0.000008091936,0.00003981768,0.0005206254,0.00001203198,0.002769287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001415054,"threshold_uncertainty_score":0.004733801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02564637702886407,"score_gpt":0.3257621961385854,"score_spread":0.3001158191097213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}