{"id":"W4388589044","doi":"10.1093/neuonc/noad179.0639","title":"PATH-09. THE IMPACT OF MISMATCH REPAIR DEFICIENCY ON GLIOMAS IN CHILDREN, ADOLESCENTS, AND YOUNG ADULTS; A MULTI-CENTRIC, COLLABORATIVE STUDY LED BY THE IRRDC AND GLIOMA TASKFORCE","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Mount Sinai Hospital; Health Sciences Centre; Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; Hospital for Sick Children","funders":"","keywords":"Microsatellite instability; Germline; DNA mismatch repair; Glioma; Germline mutation; Medicine; Somatic hypermutation; Oncology; Internal medicine; Cancer; Mutation; Cancer research; Genetics; Biology; Immunology; Allele; Microsatellite; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002396459,0.0003904401,0.0007809057,0.0014871,0.0007581768,0.001222772,0.00108547,0.0005578256,0.002922912],"category_scores_gemma":[0.00599461,0.0003899643,0.0008303314,0.00403303,0.0002726655,0.0004733295,0.00158003,0.0007084831,0.001044968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00269013,"about_ca_system_score_gemma":0.004921009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.2592254,"about_ca_topic_score_gemma":0.3110201,"domain_scores_codex":[0.9988602,0.0002714127,0.0001427669,0.0003542327,0.0001941783,0.0001771139],"domain_scores_gemma":[0.9945371,0.0007018503,0.001384893,0.0005472734,0.001448175,0.001380774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008415984,0.00003470233,0.9623345,0.0006098975,0.0006734739,0.0001124271,0.0004385303,0.0001377018,0.0002781427,0.0001990945,0.02865678,0.005683168],"study_design_scores_gemma":[0.0001506113,0.00008772092,0.9870371,0.0002353669,0.0005522129,0.0001781086,0.000517769,0.00013779,0.0000883452,0.00004776427,0.01095524,0.00001202371],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.4012975,0.002673618,0.0004703797,0.0008532957,0.00007624273,0.0003229061,0.5909229,0.00008068857,0.003302488],"genre_scores_gemma":[0.5529084,0.002319783,0.00163069,0.0005802712,0.0000870651,0.0009745697,0.4392045,0.0001311843,0.002163704],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.2592254,"threshold_uncertainty_score":0.515433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291461158880449,"score_gpt":0.3063477235235159,"score_spread":0.2934331119347114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}