{"id":"W4388589072","doi":"10.1093/neuonc/noad179.1050","title":"TMET-06. METABOLOGENOMIC CHARACTERIZATION UNCOVERS HETEROGENEITY AMONGST IDH MUTANT","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; Princess Margaret Cancer Centre; University of Toronto; Thompson Rivers University; University Health Network","funders":"","keywords":"Isocitrate dehydrogenase; Biology; Epigenetics; Glioma; IDH1; DNA methylation; Mutant; Cancer research; Genetics; Gene; Enzyme; Gene expression; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002709019,0.0002935961,0.0005112852,0.000477212,0.0001511934,0.0004833568,0.0002982481,0.0002945584,0.00149859],"category_scores_gemma":[0.0002967468,0.0001266443,0.0002368811,0.0006084017,0.000190174,0.0001636153,0.0001891153,0.0004906848,0.0003734128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003669123,"about_ca_system_score_gemma":0.0003030719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008294311,"about_ca_topic_score_gemma":0.001083585,"domain_scores_codex":[0.999851,0.00002240927,0.00001105085,0.00004497115,0.0000379863,0.00003252448],"domain_scores_gemma":[0.9998707,0.00002136319,0.0000348383,0.00001390585,0.00001426408,0.00004498126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008426538,0.0004908026,0.1362051,0.00017942,0.0001853984,0.0006223889,0.0000725409,0.002224924,0.8081249,0.0003379147,0.001596018,0.04153414],"study_design_scores_gemma":[0.0004681564,0.01010923,0.5438772,0.00003209533,0.0003869828,0.007367632,0.0002628362,0.01602676,0.4080017,0.0007849085,0.01264283,0.00003974657],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952446,0.0005657643,0.001074829,0.00009311602,0.00001654327,0.00003423588,0.002127385,0.00008790282,0.0007557868],"genre_scores_gemma":[0.9909276,0.0002449747,0.001504022,0.0000635317,0.000007872897,0.00005164101,0.006250249,0.00002411189,0.0009260357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00149859,"threshold_uncertainty_score":0.005013227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02845785927451955,"score_gpt":0.2977682020422895,"score_spread":0.26931034276777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}