{"id":"W4388589074","doi":"10.1093/neuonc/noad179.0671","title":"PATH-41. INTEGRATED MOLECULAR ANALYSIS REVEALS HYPERMETHYLATION AND OVEREXPRESSION OF HOX GENES TO BE POOR PROGNOSTICATORS IN IDH MUTANT GLIOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; Thompson Rivers University","funders":"","keywords":"Hox gene; Biology; DNA methylation; Glioma; Methylation; Oncology; Copy-number variation; Cancer research; Proportional hazards model; Gene; Genetics; Internal medicine; Gene expression; Genome; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002091826,0.0002109452,0.0001896727,0.0006037626,0.0001520793,0.0002506932,0.0001743138,0.0001167054,0.001286504],"category_scores_gemma":[0.0003853067,0.00008315207,0.000172227,0.000339961,0.0001549196,0.00006914313,0.0002500103,0.0001795595,0.0001859672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003266739,"about_ca_system_score_gemma":0.0002809766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003042898,"about_ca_topic_score_gemma":0.00439494,"domain_scores_codex":[0.9998928,0.00001567995,0.000006835809,0.00003560372,0.00002561494,0.00002342688],"domain_scores_gemma":[0.9998181,0.00003928666,0.00007024923,0.00001801222,0.00001778884,0.00003658918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001683829,0.00007319318,0.7286196,0.00007873613,0.0001281876,0.0004552313,0.00009680609,0.001531549,0.2383675,0.0002131682,0.000524609,0.02822756],"study_design_scores_gemma":[0.00002054236,0.0002499954,0.972104,0.000004503685,0.00008135138,0.0009722433,0.00004868486,0.005083446,0.02060329,0.0001551646,0.0006705315,0.000006301332],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983486,0.00009593691,0.0005135027,0.00001852711,0.000001636168,0.000007465281,0.0007401368,0.00003021871,0.0002440212],"genre_scores_gemma":[0.998341,0.00002603419,0.0007038357,0.000007362984,0.000001251849,0.000007018964,0.0007287652,0.000005599327,0.0001790866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003042898,"threshold_uncertainty_score":0.006050408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02175187963742699,"score_gpt":0.3118848497528314,"score_spread":0.2901329701154045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}