{"id":"W4388589080","doi":"10.1093/neuonc/noad179.1121","title":"TMIC-55. TURNING ENEMY INTO ALLY: HIJACK BRAIN TUMOR CELLS TO BREAK DOWN THE BLOOD-TUMOR BARRIER","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Cancer research; Wnt signaling pathway; Blood–brain barrier; Gene knockdown; Medulloblastoma; Brain tumor; Mesenchymal stem cell; Cancer stem cell; Medicine; Cancer; Signal transduction; Cell biology; Internal medicine; Biology; Pathology; Cell culture; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005738636,0.0003319281,0.0003607635,0.000114308,0.0002583403,0.00006107404,0.0006736561,0.0002167612,0.0001894939],"category_scores_gemma":[0.0005858435,0.0002704729,0.0001929882,0.0004130912,0.0001742567,0.000006876726,0.0006073583,0.0003557868,0.0005888548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003387246,"about_ca_system_score_gemma":0.0004447172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007598349,"about_ca_topic_score_gemma":0.0002526589,"domain_scores_codex":[0.9976123,0.0002892765,0.0004165369,0.000780647,0.0002266945,0.0006745255],"domain_scores_gemma":[0.9985214,0.0002716276,0.0001629571,0.0006366526,0.0001308857,0.0002765071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001150736,0.00006790445,0.0001715094,0.00003563553,0.00005411053,0.0003599664,0.0004204006,0.0001940088,0.9455706,0.00004253711,0.05009817,0.00287005],"study_design_scores_gemma":[0.000432417,0.0004117414,0.00006595708,0.000005270389,0.00003168096,0.0002156623,0.0001880637,0.00003676184,0.5134801,0.00007328075,0.4848725,0.0001864991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892674,0.000405723,0.0001395595,0.005461363,0.0008660105,0.0004373286,0.00003820924,0.00009409408,0.003290291],"genre_scores_gemma":[0.9728545,0.0001638586,0.000238965,0.02295892,0.001191267,0.0001598375,0.0001263351,0.00009296141,0.002213352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4347744,"threshold_uncertainty_score":0.9999747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007864318550274883,"score_gpt":0.2561955975863183,"score_spread":0.2483312790360434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}