{"id":"W4388589080","doi":"10.1093/neuonc/noad179.1121","title":"TMIC-55. TURNING ENEMY INTO ALLY: HIJACK BRAIN TUMOR CELLS TO BREAK DOWN THE BLOOD-TUMOR BARRIER","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Cancer research; Wnt signaling pathway; Blood–brain barrier; Gene knockdown; Medulloblastoma; Brain tumor; Mesenchymal stem cell; Cancer stem cell; Medicine; Cancer; Signal transduction; Cell biology; Internal medicine; Biology; Pathology; Cell culture; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001438586,0.0004505891,0.0004144577,0.0002528298,0.0002613782,0.0004298085,0.0003530976,0.0005412088,0.003530325],"category_scores_gemma":[0.0001169663,0.0001702153,0.0004447342,0.0001924215,0.0003432086,0.0002885528,0.0001928092,0.001504994,0.001405943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005481931,"about_ca_system_score_gemma":0.0005895908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001609669,"about_ca_topic_score_gemma":0.001965442,"domain_scores_codex":[0.9998502,0.00001261135,0.00001230087,0.00003157397,0.00003522593,0.0000581316],"domain_scores_gemma":[0.9999378,0.00000560361,0.0000125798,0.000008478509,0.000007122116,0.00002837612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000550065,0.0002520079,0.000273762,0.0001686184,0.00002853604,0.0001206767,0.00002584018,0.0004565166,0.9856328,0.0009142191,0.002477471,0.00909953],"study_design_scores_gemma":[0.0001961607,0.001518241,0.002020208,0.00002750445,0.00007936848,0.00044828,0.00004417138,0.002038122,0.972753,0.0001800913,0.02067581,0.00001900409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9559212,0.009433094,0.008165482,0.002642943,0.001035786,0.0002400111,0.003157004,0.001551997,0.01785243],"genre_scores_gemma":[0.9815407,0.003456756,0.003770753,0.0006882439,0.00005216189,0.0001304048,0.001890724,0.00006926031,0.008400947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003530325,"threshold_uncertainty_score":0.01181012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007864318550274883,"score_gpt":0.2561955975863183,"score_spread":0.2483312790360434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}