{"id":"W4388589102","doi":"10.1093/neuonc/noad179.0637","title":"PATH-07. GENOMIC AND IMMUNE ANALYSIS OF PRIMARY REPLICATION-REPAIR DEFICIENT (RRD) GLIOMAS REVEALS THREE SUBGROUPS WITH DISTINCT DRIVERS AND RESPONSE TO IMMUNOTHERAPY: AN IRRDC REPORT.","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Biology; Microsatellite instability; Glioma; Cancer research; Genome instability; ATRX; PTEN; Mutation; DNA mismatch repair; Immune system; Somatic hypermutation; Genetics; Gene; DNA repair; Allele; Microsatellite; Antibody; B cell; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001793281,0.0002162983,0.0001911289,0.0005836252,0.0001759225,0.000336164,0.0001780985,0.0002104412,0.003499554],"category_scores_gemma":[0.0001813301,0.0001420258,0.000204012,0.0003439355,0.0002121425,0.0001123004,0.0003425051,0.0002664621,0.0008254062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002614262,"about_ca_system_score_gemma":0.0002297962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003628589,"about_ca_topic_score_gemma":0.0004872715,"domain_scores_codex":[0.9998703,0.00001470132,0.00001267862,0.0000462317,0.00002004854,0.00003614654],"domain_scores_gemma":[0.9998052,0.00002541233,0.00005043297,0.00003246898,0.00002097689,0.00006555618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002853085,0.000334723,0.2364961,0.0003247663,0.0001143365,0.002549011,0.0001504918,0.000148009,0.7315348,0.0003089616,0.001032193,0.02415349],"study_design_scores_gemma":[0.0001720629,0.003321908,0.8434281,0.00002939099,0.0001949594,0.03056643,0.0002600355,0.0008625861,0.111017,0.0002527473,0.009882183,0.00001262582],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956654,0.0005128499,0.0005252094,0.0000519035,0.000008589913,0.00004795005,0.002053124,0.00004748026,0.001087634],"genre_scores_gemma":[0.9938918,0.0002750325,0.0009292883,0.00005393954,0.000009653999,0.00005479241,0.004048491,0.00001657287,0.0007205157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003499554,"threshold_uncertainty_score":0.01170725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02133296987137381,"score_gpt":0.2952102071822529,"score_spread":0.2738772373108791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}